ID A8XBS8_CAEBR Unreviewed; 739 AA.
AC A8XBS8;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Protein CBR-SEM-4 {ECO:0000313|EMBL:CAP30094.1};
GN Name=sem-4 {ECO:0000313|WormBase:CBG10785};
GN Synonyms=Cbr-sem-4 {ECO:0000313|EMBL:CAP30094.1};
GN ORFNames=CBG10785 {ECO:0000313|WormBase:CBG10785}, CBG_10785
GN {ECO:0000313|EMBL:CAP30094.1};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP30094.1, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP30094.1, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP30094.1,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the sal C2H2-type zinc-finger protein family.
CC {ECO:0000256|ARBA:ARBA00038474}.
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DR EMBL; HE600915; CAP30094.1; -; Genomic_DNA.
DR RefSeq; XP_002639963.1; XM_002639917.1.
DR AlphaFoldDB; A8XBS8; -.
DR STRING; 6238.A8XBS8; -.
DR GeneID; 8581957; -.
DR KEGG; cbr:CBG_10785; -.
DR CTD; 8581957; -.
DR WormBase; CBG10785; CBP41513; WBGene00032062; Cbr-sem-4.
DR eggNOG; KOG1074; Eukaryota.
DR HOGENOM; CLU_344259_0_0_1; -.
DR InParanoid; A8XBS8; -.
DR OMA; DIREHKC; -.
DR OrthoDB; 2880677at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048333; P:mesodermal cell differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0042692; P:muscle cell differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0048626; P:myoblast fate specification; IEA:EnsemblMetazoa.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR GO; GO:0014016; P:neuroblast differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:EnsemblMetazoa.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006979; P:response to oxidative stress; IEA:EnsemblMetazoa.
DR GO; GO:0060290; P:transdifferentiation; IEA:EnsemblMetazoa.
DR GO; GO:0072326; P:vulval cell fate determination; IEA:EnsemblMetazoa.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23233:SF84; FI23031P1-RELATED; 1.
DR PANTHER; PTHR23233; SAL-LIKE PROTEIN; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF12874; zf-met; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 97..127
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 129..156
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 304..331
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 332..359
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 583..610
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 611..638
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 11..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..208
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 80656 MW; 5FECF3A9C959B469 CRC64;
MNELLAEMAA VSSRRKQMKP RRMSGEGDAM MSPIDLSTKS FDENNCEKSA LPLEDRSNIL
PHFPVPFTNP QQFLSLCAQL GNSTSSRNVS STASTTSSCP IQSCSQSFSS AAALTWHVLD
AHEDEQEVFS CDGCGTTFSN GQDIREHKCS KSGASRSSSV PPSTVPSGAC FLSTPTTPCP
QFSINESIGT SSEIRDEEEE EDMDSEDNEQ VASQLFGQLL QKSDDPRAKI SSLFNNALPQ
FAGFPNVPPH FLMRQPFDPR AEIFASRHEN DDDWEALMEI STSDEAEKIR ALVGDKAVPT
TDPNQCILCR RVLSCKSALQ MHYRTHTGER PFKCKICQRA FTTKGNLKTH MGVHRSKHSF
RGLPISLPPQ LAAAHQMPPR LHIQTPPTSA AAAAAAVAQI QSQAGQQCPI CQQRLMNAQE
MAVHIAEHRN SLTQPPRVMP SPQTRVQTFP FVPFFTPPSL NATDMSTQFN LANILSAQLK
NDSSPNTDTS SVEEKVIRDD PPKMASLSPS NSSESSSSVR QETLEANELD GKKYDEPPVL
EQQVSPAPPP TNSKNENPLL AMQKMWAETE PPPPRAMPVL SKHQCGVCFK HFSSSSALQI
HMRTHTGDKP FKCEMCGRAF TTRGNLKVHM GTHSWQQSPS RRGRRIFDVA TGGGPANEKP
MMPNPILANG GGPGASPLAM LGPSGISGLE MMMMLWRTVC SVCQKVCTSP TELEQHLKEH
LSNGNSKTPI PSAATPPPS
//
