ID A8XEG4_CAEBR Unreviewed; 365 AA.
AC A8XEG4;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Protein CBG12059 {ECO:0000313|EMBL:CAP31099.1};
GN Name=poml-4 {ECO:0000313|WormBase:CBG12059};
GN Synonyms=poml-3 {ECO:0000313|WormBase:CBG12059};
GN ORFNames=CBG12059 {ECO:0000313|EMBL:CAP31099.1,
GN ECO:0000313|WormBase:CBG12059}, CBG_12059
GN {ECO:0000313|EMBL:CAP31099.1};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP31099.1, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP31099.1, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP31099.1,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR602640-2};
CC Note=Binds 2 calcium ions per subunit. {ECO:0000256|PIRSR:PIRSR602640-
CC 2};
CC -!- SIMILARITY: Belongs to the paraoxonase family.
CC {ECO:0000256|ARBA:ARBA00008595}.
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DR EMBL; HE601540; CAP31099.1; -; Genomic_DNA.
DR RefSeq; XP_002646345.1; XM_002646299.1.
DR AlphaFoldDB; A8XEG4; -.
DR STRING; 6238.A8XEG4; -.
DR EnsemblMetazoa; CBG12059.1; CBG12059.1; WBGene00033067.
DR GeneID; 8588342; -.
DR KEGG; cbr:CBG_12059; -.
DR CTD; 8588342; -.
DR WormBase; CBG12059; CBP17346; WBGene00033067; Cbr-poml-4.
DR eggNOG; ENOG502S3B5; Eukaryota.
DR HOGENOM; CLU_049839_1_0_1; -.
DR InParanoid; A8XEG4; -.
DR OMA; RTYKAES; -.
DR OrthoDB; 2874974at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0004064; F:arylesterase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR002640; Arylesterase.
DR PANTHER; PTHR11799; PARAOXONASE; 1.
DR PANTHER; PTHR11799:SF7; PON (PARAOXONASE) AND MEC-6 LIKE-RELATED; 1.
DR Pfam; PF01731; Arylesterase; 1.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR602640-2};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR602640-3};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602640-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549}.
FT ACT_SITE 111
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602640-1"
FT BINDING 49
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR602640-2"
FT BINDING 50
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR602640-2"
FT BINDING 113
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR602640-2"
FT BINDING 165
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR602640-2"
FT BINDING 166
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR602640-2"
FT BINDING 220
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR602640-2"
FT BINDING 266
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR602640-2"
FT BINDING 267
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR602640-2"
FT DISULFID 38..357
FT /note="In form B"
FT /evidence="ECO:0000256|PIRSR:PIRSR602640-3"
SQ SEQUENCE 365 AA; 41261 MW; EA42BF73770BB1CE CRC64;
MLKIVLVVLL AFLVQYVFKT LLMFDVQKRI YNHRPGQCRK IEGPVHGSED ITIVDEKYVA
FITSGLVYLN DDPSRATWKG QIFLYDLTKR TYKAESIPIL NLEDEEGFHP HGISHWIKKD
GTIRLFIVVH SKIFKHSIVI LDFDETKRQL NHVRTVRNEK FVRPNDIVAT GDDSFLVSND
GGAQTVLGNA VEMFTGFWKG GLVYYDGKTS QYLLENTVAN GIILSRDRKT LFVSHINQET
IGVFAWDQKN ISIKKISEIE TLTGCDNFYI DKQDNLWSGC HPILKDAVGH LGDAGDQSLF
APSQVLRFKF SKDLKSAEMV EVFSDDGKFT SASAIAVGFD DGKQLLIGTV FRDLTHCDID
VPLDF
//
