ID A8XF30_CAEBR Unreviewed; 978 AA.
AC A8XF30;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 24-JAN-2024, entry version 101.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=ncl-1 {ECO:0000313|WormBase:CBG12245};
GN Synonyms=Cbr-ncl-1 {ECO:0000313|EMBL:CAP31252.2};
GN ORFNames=CBG12245 {ECO:0000313|WormBase:CBG12245}, CBG_12245
GN {ECO:0000313|EMBL:CAP31252.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP31252.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP31252.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP31252.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family.
CC {ECO:0000256|ARBA:ARBA00008518}.
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DR EMBL; HE600962; CAP31252.2; -; Genomic_DNA.
DR AlphaFoldDB; A8XF30; -.
DR STRING; 6238.A8XF30; -.
DR WormBase; CBG12245; CBP43525; WBGene00033222; Cbr-ncl-1.
DR eggNOG; KOG2177; Eukaryota.
DR HOGENOM; CLU_007697_0_0_1; -.
DR InParanoid; A8XF30; -.
DR OMA; CCTLVCK; -.
DR OrthoDB; 5387006at2759; -.
DR Proteomes; UP000008549; Chromosome III.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19813; Bbox1_BRAT-like; 1.
DR CDD; cd19798; Bbox2_BRAT-like; 1.
DR CDD; cd14959; NHL_brat_like; 1.
DR Gene3D; 4.10.830.40; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24104:SF41; BRAIN TUMOR PROTEIN; 1.
DR PANTHER; PTHR24104; E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED; 1.
DR Pfam; PF01436; NHL; 4.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00336; BBOX; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51125; NHL; 5.
DR PROSITE; PS50119; ZF_BBOX; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 79..119
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 244..291
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 339..382
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT REPEAT 700..743
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 747..792
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 793..834
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 835..877
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 878..921
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REGION 195..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 429..460
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 978 AA; 105246 MW; 8EACD2A7367A7A39 CRC64;
MSESESLGGS SASTTTTAGS DEYTMSQIFG TAGRPIPLST FAGVAIPNSW GSAVSQPMLA
GSFGLAPTPP PVIQEIIKCT LCLEPYRDPK VLACFHSFCK GCLAKHLEQP ERIICPQCNM
ETQLSVQLGL DSLLTDFGLE SVMNKQQQLF ANLALSENGN GGAPTPSAAI PVPNAHLRPS
MVAGSDPSNP VVGFGFSSPT SSTSGSPPLS DSPTIEEQHQ AQIAAMMQGL LNNNAAVAPV
IAPVPAVHCN GCKSNETATS FCQDCNANLC DNCTMAHKYM HCFADHRVVE LTPAGSSASS
TTSSTPSSSD SERSQLLASL GGKHSPQAAA AMMLLGNGKR PVLCLQHRAS ELVFFCVTCN
LAICRDCTQA DHPAGTHQYE LISDVADKQL LKMEQLIADA RNKHADMLDM FKQVDSKQQI
LTASLHNAHA QLDETVSTLL QAIQEQKKQL SKEIDNAFAA KQVIQLTMVD KRIQSMADKL
SQTIEFSRRL MSFSSPAEVM VFKQLLDTRL QLFLGFNPDT SGVLNTSCEI EYLGAAGLYS
NSSSAVQQLL GSVRGGNSNP IAIPNDFLMP SAQTGMPPTP IGRAPGSTRG IQIEQNGLSR
SPPHHVAASL PMNAFSDSNL LRPNKDFGGS SQSLGPFSAL NGAAASADPF SSQYDKWSLG
VEPVGSVGGL LEGGNVDEEK FQTLFPPSRS QIKRQKMIYH CKFGEFGVME GQFTEPSGVA
VNGQGDIVVA DTNNHRIQVF DKDGRFKFQF GECGKRDGQL LYPNRVAVNR TTGDFVVTER
SPTHQIQVYN QYGQFLRKFG ANILQHPRGV CVDNKGRIIV VECKVMRVII FDMFGNILQK
FSCSRYLEFP NGVCTNDKNE ILISDNRAHC IKVFSYEGQY LRQIGGEGVT NYPIGVGINS
LGEVVVADNH NNFNLTVFSQ DGTMIGALES RVKHAQCFDV ALVDDGSVVL ASKDYRLYLY
RFLPASPSTA AAAGTGQI
//