ID A8XFA0_CAEBR Unreviewed; 643 AA.
AC A8XFA0;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Protein CBR-TWK-30 {ECO:0000313|EMBL:CAP31361.2};
GN Name=twk-30 {ECO:0000313|WormBase:CBG12373};
GN Synonyms=Cbr-twk-30 {ECO:0000313|EMBL:CAP31361.2};
GN ORFNames=CBG12373 {ECO:0000313|WormBase:CBG12373}, CBG_12373
GN {ECO:0000313|EMBL:CAP31361.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP31361.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP31361.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP31361.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR EMBL; HE600913; CAP31361.2; -; Genomic_DNA.
DR AlphaFoldDB; A8XFA0; -.
DR STRING; 6238.A8XFA0; -.
DR WormBase; CBG12373; CBP17504; WBGene00033331; Cbr-twk-30.
DR eggNOG; KOG1418; Eukaryota.
DR HOGENOM; CLU_030527_0_0_1; -.
DR InParanoid; A8XFA0; -.
DR OMA; IILTTMC; -.
DR OrthoDB; 5010334at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR PANTHER; PTHR11003:SF113; TWIK FAMILY OF POTASSIUM CHANNELS; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SMART; SM00060; FN3; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
DR PROSITE; PS50853; FN3; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 12..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 399..491
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 492..586
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 643 AA; 74807 MW; 5E8ACD8683EB7212 CRC64;
MSCFQVESNK MAKFLSLHVL LIGSVILYII LGAIVFQMLE GEHLDALKKD HMDRIDQNAK
DYVNRLWDLA KENKNNYGTV DDLIKFVKSE TVDDFNNYVD TVFYAHRAVR HGYDEVDPDI
VIFDSPTWDF ANSVFFTTTM LTSIGYGYVA PSTFGGRLFG VIYCLIGIPL TLVTVANVAK
FLSETIFFLH YELWNKCLEW KRKRKGEVEA DPAQPMFGDD ENEEEILDRV RLVRFPPLTV
FMFVFVYGCI AAWVVRYWET WTYVESLYFI FISILTVGFG DIRPSPGNIW VTLAFVVVGV
ILTTMCMDVV GRMYLKEIHY LGRKLKSNNP FYLLREAKAR RRRAAMASLL AQLAKGMIFA
HKDYNELARK KSKRKKEKRR GSHVLPNEKF MFARLPPDPP SDCQVVSTSA YSVRLAWAPP
FSPDPDLTYN IRYRLKHNED AKVRELRGIK GNTVEIMSVD SCSLYEFRIT AHNKFGESKA
VYLVQYTEPQ LSPQHILATR LNANTIELTW EPPYKKSHEV KNYVVYFTEN PNASLSEWEK
IPVNGRRVVF PDLRFDWFYM FSATAVFKDG QRSPLSRALF IKTDKIEFHK HLALSRNGLK
SKHYKLPHNF ETYAESGIYF WRVCFTCKHK MCRRKSILRL RNM
//