ID A8XPD4_CAEBR Unreviewed; 315 AA.
AC A8XPD4;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=GDP-L-fucose synthase {ECO:0000256|ARBA:ARBA00012371};
DE EC=1.1.1.271 {ECO:0000256|ARBA:ARBA00012371};
DE AltName: Full=GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase {ECO:0000256|ARBA:ARBA00032995};
GN Name=ger-1 {ECO:0000313|WormBase:CBG16511};
GN Synonyms=Cbr-ger-1 {ECO:0000313|EMBL:CAP34455.1};
GN ORFNames=CBG16511 {ECO:0000313|WormBase:CBG16511}, CBG_16511
GN {ECO:0000313|EMBL:CAP34455.1};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP34455.1, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP34455.1, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP34455.1,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Catalyzes the two-step NADP-dependent conversion of GDP-4-
CC dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a
CC reductase reaction. {ECO:0000256|ARBA:ARBA00002870}.
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via
CC de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004883}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Fucose synthase subfamily. {ECO:0000256|ARBA:ARBA00005959}.
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DR EMBL; HE600949; CAP34455.1; -; Genomic_DNA.
DR RefSeq; XP_002641838.1; XM_002641792.1.
DR AlphaFoldDB; A8XPD4; -.
DR STRING; 6238.A8XPD4; -.
DR EnsemblMetazoa; CBG16511.1; CBG16511.1; WBGene00036425.
DR GeneID; 8583832; -.
DR KEGG; cbr:CBG_16511; -.
DR CTD; 8583832; -.
DR WormBase; CBG16511; CBP04027; WBGene00036425; Cbr-ger-1.
DR eggNOG; KOG1431; Eukaryota.
DR HOGENOM; CLU_007383_18_2_1; -.
DR InParanoid; A8XPD4; -.
DR OMA; HPSNYGY; -.
DR OrthoDB; 5474548at2759; -.
DR UniPathway; UPA00128; UER00191.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0050577; F:GDP-L-fucose synthase activity; IBA:GO_Central.
DR GO; GO:0042351; P:'de novo' GDP-L-fucose biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05239; GDP_FS_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR HAMAP; MF_00956; GDP_fucose_synth; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR028614; GDP_fucose/colitose_synth.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43238; GDP-L-FUCOSE SYNTHASE; 1.
DR PANTHER; PTHR43238:SF1; GDP-L-FUCOSE SYNTHASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549}.
FT DOMAIN 4..238
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 315 AA; 35584 MW; DBD9FAF395B251F6 CRC64;
MKTILVTGGT GLVGSAIRQV VESTEKRDDE KWVFIGSKDC DLENVEETRK LFESVKPTHV
IHLAAMVGGL FHNLAHNLKF FRKNMAINDN VLALCHEFDV VKCVSCLSTC IFPDKTTYPI
DETMVHLGPP HDSNFGYSYA KRMIDVLNKG YAQEHGRKYT SVIPCNVFGP HDNYNLQAGH
VLPALIHKAF VAKRDNTSLE VFGSGKPLRQ FIYSMDLARL FVRVVREYED VEPLILSVGE
SDEVSIRDAV SAVVKAMEFT GNVEYDTSKA DGQFKKTASN EKLLKLFPDF KFTPFEQAIQ
ESVQWFVENY ETARK
//
