ID A8XQW9_CAEBR Unreviewed; 455 AA.
AC A8XQW9;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=Protein CBR-NHR-33 {ECO:0000313|EMBL:CAP35044.2};
GN Name=hizr-1 {ECO:0000313|WormBase:CBG17366};
GN Synonyms=Cbr-nhr-33 {ECO:0000313|EMBL:CAP35044.2}, nhr-33
GN {ECO:0000313|WormBase:CBG17366};
GN ORFNames=CBG17366 {ECO:0000313|WormBase:CBG17366}, CBG_17366
GN {ECO:0000313|EMBL:CAP35044.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP35044.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP35044.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP35044.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|ARBA:ARBA00005993, ECO:0000256|RuleBase:RU004334}.
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DR EMBL; HE600924; CAP35044.2; -; Genomic_DNA.
DR AlphaFoldDB; A8XQW9; -.
DR STRING; 6238.A8XQW9; -.
DR WormBase; CBG17366; CBP40955; WBGene00037013; Cbr-hizr-1.
DR eggNOG; KOG3575; Eukaryota.
DR HOGENOM; CLU_007368_1_1_1; -.
DR InParanoid; A8XQW9; -.
DR OMA; EADVCCK; -.
DR OrthoDB; 2879924at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblMetazoa.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:EnsemblMetazoa.
DR GO; GO:0071294; P:cellular response to zinc ion; IEA:EnsemblMetazoa.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:EnsemblMetazoa.
DR GO; GO:0040008; P:regulation of growth; IEA:EnsemblMetazoa.
DR CDD; cd06960; NR_DBD_HNF4A; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR049636; HNF4-like_DBD.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR46011:SF33; HIGH ZINC ACTIVATED NUCLEAR RECEPTOR PROTEIN; 1.
DR PANTHER; PTHR46011; NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-86-RELATED; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 59..134
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 199..455
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
SQ SEQUENCE 455 AA; 51612 MW; 2CD3FA11DF9D4FBA CRC64;
MFTPSGTSIP HSFPDHIIRP IPQYSPGVVI QTIQQIPEST PQGNTPQGII PQADTVEERE
DCKICFQIAD GVHFGVASCR ACAAFFRRTV IMKLKYMCKD KGNCTVEKSL RNLCRSCRYT
RCLNEGMKIE CKSTKQGSVS FFDLFTVVQL QRDSIGKKKS VGNTSVDLLF TPNVASSLSA
VFKKDKEESL TPECTILSQM SCGYDFFLKF RKSTNTLVQS TVITPTFRIP KIELHASRFD
SAKQVSKVEA HLVTDIVNTY FSPFNVLKFK DKVALFKNFF CYFSHTDRAY QSYKQFENDN
VNDKILMPDG GFIKRTELGR FYENAEGVHT SAEDAAQIFQ PVFNYILDVI VDYMRRIHII
EIEYLAILGF CLWDDAVPGL SKEAKSLAVR TQSQILAELQ SYYASKKCVI MLRENSVLAE
LFNYYEADVC CKNFKEDASV DLDCKAECIV HSKNE
//
