ID A8XW73_CAEBR Unreviewed; 1151 AA.
AC A8XW73;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=Protein CBR-TAG-182 {ECO:0000313|EMBL:CAP36892.2};
GN Name=nfx-1 {ECO:0000313|WormBase:CBG19688};
GN Synonyms=Cbr-tag-182 {ECO:0000313|EMBL:CAP36892.2}, tag-182
GN {ECO:0000313|WormBase:CBG19688};
GN ORFNames=CBG19688 {ECO:0000313|WormBase:CBG19688}, CBG_19688
GN {ECO:0000313|EMBL:CAP36892.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP36892.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP36892.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP36892.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NFX1 family.
CC {ECO:0000256|ARBA:ARBA00007269}.
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DR EMBL; HE600934; CAP36892.2; -; Genomic_DNA.
DR AlphaFoldDB; A8XW73; -.
DR STRING; 6238.A8XW73; -.
DR WormBase; CBG19688; CBP19678; WBGene00038863; Cbr-nfx-1.
DR eggNOG; KOG1952; Eukaryota.
DR HOGENOM; CLU_005714_0_0_1; -.
DR InParanoid; A8XW73; -.
DR OMA; KAHHGTW; -.
DR OrthoDB; 1412at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd06008; NF-X1-zinc-finger; 6.
DR InterPro; IPR034078; NFX1_fam.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR000967; Znf_NFX1.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR12360; NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1; 1.
DR PANTHER; PTHR12360:SF12; TRANSCRIPTIONAL REPRESSOR NF-X1; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF01422; zf-NF-X1; 7.
DR SMART; SM00393; R3H; 1.
DR SMART; SM00438; ZnF_NFX; 10.
DR SUPFAM; SSF82708; R3H domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 230..283
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 900..970
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT REGION 1..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..836
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1079..1121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1151 AA; 128578 MW; FA3B1FDB13B21E47 CRC64;
MADTIEASSN IATSSNPPRQ GPKRGRGGRF RQAPREGGAE IAAGNQDAAP QMNPRGGRRG
FNGNRRGKAQ KEGLDIDKFI VFQRKRFLGP SGRQPQPKPL HAFNPNAPVF NPSVPPPELP
ASTTEGPSNQ KRQNPNPRRR GGQGGQQNEQ RRQLEIQEGR QPNRNQSGPN RPDRREENRR
GAPGNYRRGQ GARRREQKEE QLTEEETAML ADKPLRERLV YMLENNKYEC AICYTRITTR
QGVWSCKTCY HIFHISTGCI TDWAKSSRDK EAGSNTWRCP TCQTENETMP YNYYCFCGKQ
RNPNFRVGEV PHSCGEICGG TRKFGCPHPC NELCHPGPCS ECKLYVTKSC NCGKTKKSVR
CGSGQSVLVR SSFLYDILIR ILKFCFQCDT VCGKTLPCGQ HTCEKICHSG ECGDCTVVLE
QECFCGKKPK EVVCNPTACQ KYSCGSECDG MFSCGVHRCT KKCHGKECGD CETGVNRIRT
CPCGRNSLQS LGIVREKCTD KVPTCDSICD KWLTCGTPGK NHRCREKCHE DQCPPCNLNT
SVVCRCGSSK GVILCEEYLE IMRTSEFWGG GFQWKTKRKF SAGEYLCTKR CRKKKSCGMH
KCQEVCCIQD EHYCLQMCNK RLSCGIHTCE NVCHAGQCRP CLQASFDEQF CHCGHTVRMP
PIPCGARLPV CSQPCVRPHS CDHPVNHKCH GEPNCPPCTH LTDKTCYGGH TVRKNIPCHI
QSVSCGVICQ KPLKCGVHVC QRTCHGDECE KEGEQCTKKC EAIRERCEHP CGLPCHKDSP
CEPSPCKTNV QITCECGRLK KAAPCCEVDK LIEAKQEKEE TEKSGDSGDS GDQDKPGKLV
RSSSFSQLNC MKCDDDCKKL ERNRKVAEAL EVDTDEYGMN KLTPTISFPC YLKAMVRANI
DFVKNVEKVF IDLVIKVLSG EAYHDVFRAH LPPMSIEKRR FVHEYANFFN IVSESVDSPP
KRSIVLTAVR GKSHQPLILI SDLVNYKGAL KAPGPAVVRK DLMDQAMSKK EESEGTMKPL
RCTEKMVVRR EARPMKEIAA PIPLKQQNQF ALLGSDVDSD DEESKPTTSA AAGSSPPKDW
WNDEEEPGWQ KVQQKEFVVE VERDMTEEEI EAAKLIEEGP TWEDQADEDS PGVSTAEAAT
PTEPSIVKNP E
//
