ID   A8Y0A3_CAEBR            Unreviewed;       185 AA.
AC   A8Y0A3;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   27-MAR-2024, entry version 101.
DE   SubName: Full=Protein CBR-ARL-8 {ECO:0000313|EMBL:CAP38288.1};
GN   Name=arl-8 {ECO:0000313|WormBase:CBG21511};
GN   Synonyms=Cbr-arl-8 {ECO:0000313|EMBL:CAP38288.1};
GN   ORFNames=CBG21511 {ECO:0000313|WormBase:CBG21511}, CBG_21511
GN   {ECO:0000313|EMBL:CAP38288.1};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP38288.1, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP38288.1, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP38288.1,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004656}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000256|ARBA:ARBA00010290}.
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DR   EMBL; HE601157; CAP38288.1; -; Genomic_DNA.
DR   RefSeq; XP_002632607.1; XM_002632561.1.
DR   AlphaFoldDB; A8Y0A3; -.
DR   STRING; 6238.A8Y0A3; -.
DR   EnsemblMetazoa; CBG21511.1; CBG21511.1; WBGene00040259.
DR   GeneID; 8574603; -.
DR   KEGG; cbr:CBG_21511; -.
DR   CTD; 8574603; -.
DR   WormBase; CBG21511; CBP05104; WBGene00040259; Cbr-arl-8.
DR   eggNOG; KOG0075; Eukaryota.
DR   HOGENOM; CLU_040729_10_0_1; -.
DR   InParanoid; A8Y0A3; -.
DR   OMA; FRNMWER; -.
DR   OrthoDB; 607297at2759; -.
DR   Proteomes; UP000008549; Unassembled WGS sequence.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0048786; C:presynaptic active zone; IEA:EnsemblMetazoa.
DR   GO; GO:0008021; C:synaptic vesicle; IEA:EnsemblMetazoa.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0008089; P:anterograde axonal transport; IBA:GO_Central.
DR   GO; GO:0008333; P:endosome to lysosome transport; IEA:EnsemblMetazoa.
DR   GO; GO:0015031; P:protein transport; IEA:InterPro.
DR   GO; GO:1903742; P:regulation of anterograde synaptic vesicle transport; IEA:EnsemblMetazoa.
DR   CDD; cd04159; Arl10_like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR044154; Arl8a/8b.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR45732; ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8; 1.
DR   PANTHER; PTHR45732:SF7; ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00177; ARF; 1.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00173; RAS; 1.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51417; ARF; 1.
DR   PROSITE; PS51419; RAB; 1.
DR   PROSITE; PS51422; SAR1; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549}.
SQ   SEQUENCE   185 AA;  21299 MW;  E89D846BA541DF37 CRC64;
     MMAMVNKVLD WIRSLFWKEE MELTLVGLQN SGKTTFVNVI ASGQFTEDMI PTVGFNMRKI
     TKGNVTIKLW DIGGQPRFRS MWERYCRGVN AIVFMVDAAD EEKLEASRNE LMQLLDKPQL
     DAIPVLVLGN KKDLPGALDE RQLIERMNLS SIQNREICCY SISCKEKENI DITLQWLIDH
     SKAQR
//