ID A8Y3J3_CAEBR Unreviewed; 700 AA.
AC A8Y3J3;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Anaphase-promoting complex subunit 2 {ECO:0000256|ARBA:ARBA00016068};
GN Name=apc-2 {ECO:0000313|WormBase:CBG22973};
GN Synonyms=Cbr-apc-2 {ECO:0000313|EMBL:CAP39462.2};
GN ORFNames=CBG22973 {ECO:0000313|WormBase:CBG22973}, CBG_22973
GN {ECO:0000313|EMBL:CAP39462.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP39462.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP39462.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP39462.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
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DR EMBL; HE600964; CAP39462.2; -; Genomic_DNA.
DR AlphaFoldDB; A8Y3J3; -.
DR STRING; 6238.A8Y3J3; -.
DR WormBase; CBG22973; CBP38820; WBGene00041413; Cbr-apc-2.
DR eggNOG; KOG2165; Eukaryota.
DR HOGENOM; CLU_380467_0_0_1; -.
DR InParanoid; A8Y3J3; -.
DR OMA; ENTHFAR; -.
DR OrthoDB; 2786196at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044554; APC2-like.
DR InterPro; IPR014786; APC2_C.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45957; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR45957:SF1; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR Pfam; PF00888; Cullin; 1.
DR SMART; SM01013; APC2; 1.
DR SMART; SM00182; CULLIN; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 352..584
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 700 AA; 80305 MW; AF6460D5F66692C9 CRC64;
MSLFDRMTTS PEAARQYREF CISKKREVWE ALIQYSKQAK HIEKVYDMTT VLQRVQQECL
VFALDNGIGN PDVHHAAELI FPLSMQKVVI QVLRPYFLSH WANFRLAGYN PIRKIDHGID
LNEDLWTDQK KERNQQYVHD FTAFVNELKT GIVNANRHIN AAVSLYIREL AASMVMHEKQ
AFDNELRCSM LQEYMESLRI WADAMTLQDA YHLVSDQIYK DVFQMLSKNA YEMVAVQFPQ
KFREIITMKY CLMKTGNYGR DALTKRLIFS VETNLLIASV DTKTILQAYA SCVEALREMD
SSCVVMHKVC GVIREYLKRR PDTVQQIITY ITSSKKNELE KDMSKTVRSA MMDEEELRGV
NDDFLPENME CKGWDTWTPN PTDANVGDGA PGRQGVDVFN MLVSVYGSKE LFVKEYRNLL
AERLSGSDKK DAFFEKRYLD LLKLRFQYSE LQHCEVMLRD VMQSQEIDCR CENVRELTPG
MIPVSGCVAS SHYWPKLEHE TTTKELADLY PPSLLAAVAA YEGMYAMNKR DRKMFVYKCV
GCMELEIEVD GVKIERTIPN AFAQALLLFL EKENPVISSD TWSLTKNAAG ILPNQAGAPE
VADDEDVEPE ENSDMVDALE QYWGYTKNYI ANHSPNGEVK AERMHRVYRM FGSPTSAGPS
IDHVTAFLQR KVALGLLTCI NGSYRVVEEK KKANENPEGQ
//
