ID A8Y419_CAEBR Unreviewed; 450 AA.
AC A8Y419;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=Protein CBR-NHR-136 {ECO:0000313|EMBL:CAP39639.2};
GN Name=nhr-136 {ECO:0000313|WormBase:CBG23383};
GN Synonyms=Cbr-nhr-136 {ECO:0000313|EMBL:CAP39639.2};
GN ORFNames=CBG23383 {ECO:0000313|WormBase:CBG23383}, CBG_23383
GN {ECO:0000313|EMBL:CAP39639.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP39639.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP39639.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP39639.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|ARBA:ARBA00005993, ECO:0000256|RuleBase:RU004334}.
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DR EMBL; HE601533; CAP39639.2; -; Genomic_DNA.
DR AlphaFoldDB; A8Y419; -.
DR STRING; 6238.A8Y419; -.
DR WormBase; CBG23383; CBP42233; WBGene00041748; Cbr-nhr-136.
DR eggNOG; ENOG502TGMR; Eukaryota.
DR HOGENOM; CLU_007368_3_1_1; -.
DR InParanoid; A8Y419; -.
DR OMA; CLLNYGS; -.
DR OrthoDB; 2875926at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0042594; P:response to starvation; IEA:EnsemblMetazoa.
DR CDD; cd06960; NR_DBD_HNF4A; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR049636; HNF4-like_DBD.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24083:SF171; NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-136; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 50..144
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 181..445
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
SQ SEQUENCE 450 AA; 50781 MW; 8C78A1CB1868AC16 CRC64;
MLPDIISVPS TSVKCLSSEV LLPEDVGECE ELEYKITKTQ KPMMNRGACP SMCKVCRHPA
TGYHYDVPSC NGCKTFFRRS ILDGRKYTCL KMKKCLSGNE PVGMCLFEKF SKEILFPDLT
KRMCRSCRFE QCVEAGMNPS AIQADVKSSD GEILKNEIMR KQKGSVDGLS TPHVLLSFED
KVNEIIEKLT SMEVKIEPLY TEGLPPGYKD NRKLEDVINS PMILRYDEIP NLEYCPVIDE
STGQIKSSGA CYIHCCYLAS IEYSKMFDFV NKIDAANKII LVKHATVMCA DIMTSFFSYD
RLKSDKLIHP NGLFAGPPRP RYGEVGAKHQ AGMQRTLVTV LRNELNRVEY LLLKAIVLCN
PAVSGLTETV QEVIGKEREQ YVRTLLTYCL LNYGSVHGPS RFSALLAIMS VLESQQRNAK
DFHLLAKATV LKDLVRYTRV SQLYEQIMES
//