ID A8YTN7_LACH4 Unreviewed; 275 AA.
AC A8YTN7;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Aldehyde reductase {ECO:0000313|EMBL:ABX27861.1};
GN OrderedLocusNames=lhv_2076 {ECO:0000313|EMBL:ABX27861.1};
OS Lactobacillus helveticus (strain DPC 4571).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=405566 {ECO:0000313|EMBL:ABX27861.1, ECO:0000313|Proteomes:UP000000790};
RN [1] {ECO:0000313|EMBL:ABX27861.1, ECO:0000313|Proteomes:UP000000790}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DPC 4571 {ECO:0000313|EMBL:ABX27861.1,
RC ECO:0000313|Proteomes:UP000000790};
RX PubMed=17993529; DOI=10.1128/JB.01295-07;
RA Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K.,
RA McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F.,
RA Beresford T., Ross R.P.;
RT "Genome sequence of Lactobacillus helveticus: an organism distinguished by
RT selective gene loss and IS element expansion.";
RL J. Bacteriol. 190:727-735(2008).
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DR EMBL; CP000517; ABX27861.1; -; Genomic_DNA.
DR RefSeq; WP_004561127.1; NC_010080.1.
DR AlphaFoldDB; A8YTN7; -.
DR KEGG; lhe:lhv_2076; -.
DR eggNOG; COG0656; Bacteria.
DR HOGENOM; CLU_023205_2_3_9; -.
DR Proteomes; UP000000790; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43638; OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR43638:SF3; OXIDOREDUCTASE, ALDO_KETO REDUCTASE FAMILY PROTEIN; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE 4: Predicted;
FT DOMAIN 9..260
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 47
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 106
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 73
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 275 AA; 31082 MW; 5A2B2A49675B5CD0 CRC64;
MDFEKLSGLG IGTWGIGEDP KKKKDEIAAI RYGLDNGLNI IDTAEMYGDG KSEKLIGEAI
RDYDRDQLFL ISKFYPYHAT PELERKSLEA SLERLGTDYL DLYLLHWRGN HRLSDTIRGL
QALQKEGLIR HWGVSNFDTS DMKELFGVPG GTECFANEDL YNIKERGTEF DLQDWQKDHG
VSFIGYSPFN SGAGDTIRIT QNLKIVARDH GVTPHQIMLA WTLRNGNVLA IPKSSSIKHM
KENIAAQEIK LTDDELRLIN SDFPIPTEKT PLAVI
//
