ID   A8YU92_LACH4            Unreviewed;       729 AA.
AC   A8YU92;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   SubName: Full=ATP-dependent Clp protease, ATP-binding subunit {ECO:0000313|EMBL:ABX26830.1};
GN   OrderedLocusNames=lhv_0683 {ECO:0000313|EMBL:ABX26830.1};
OS   Lactobacillus helveticus (strain DPC 4571).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=405566 {ECO:0000313|EMBL:ABX26830.1, ECO:0000313|Proteomes:UP000000790};
RN   [1] {ECO:0000313|EMBL:ABX26830.1, ECO:0000313|Proteomes:UP000000790}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DPC 4571 {ECO:0000313|EMBL:ABX26830.1,
RC   ECO:0000313|Proteomes:UP000000790};
RX   PubMed=17993529; DOI=10.1128/JB.01295-07;
RA   Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K.,
RA   McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F.,
RA   Beresford T., Ross R.P.;
RT   "Genome sequence of Lactobacillus helveticus: an organism distinguished by
RT   selective gene loss and IS element expansion.";
RL   J. Bacteriol. 190:727-735(2008).
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|RuleBase:RU004432}.
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DR   EMBL; CP000517; ABX26830.1; -; Genomic_DNA.
DR   RefSeq; WP_012211586.1; NC_010080.1.
DR   AlphaFoldDB; A8YU92; -.
DR   KEGG; lhe:lhv_0683; -.
DR   eggNOG; COG0542; Bacteria.
DR   HOGENOM; CLU_005070_4_0_9; -.
DR   Proteomes; UP000000790; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 4.10.860.10; UVR domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW   Hydrolase {ECO:0000313|EMBL:ABX26830.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:ABX26830.1}.
FT   DOMAIN          350..385
FT                   /note="UVR"
FT                   /evidence="ECO:0000259|PROSITE:PS50151"
SQ   SEQUENCE   729 AA;  81689 MW;  5B0F7597B089863B CRC64;
     MLCQNCYKRP ASIHLFTKVN GQSREIDLCQ QCYQELKNQQ GNLENMNNNN EFFGDFDDLF
     NALNGNNNNA ANNNMNENNP RMQMGGGNGN GNHGGKSLLD QYGTDLTALA KKGKIDPVIG
     RDKEIARVIE ILNRRTKNNP VLIGEAGVGK TAVVEGLAQE IVDGSVPAKL QNKRIISLNV
     VSLVQGTGIR GQFEQRMEQL IKELQQNDDI ILFIDEIHEI VGAGNAEGGM DAGNIIKPAL
     ARGELQLVGA TTIKEYRDIE KDSALARRFQ PVEVKEPPID ETIRILKGIQ QRYEDYHHVH
     YTDDAIEAAA KLSARYIQDR FLPDKAIDLL DEAGSRMNLT IPYIDKDKMQ ERINAAEQLK
     KEALKNEDYE KAAYYRDQIE KYEKVKDQKV DPDKSPVITN KIMNKIVEEK TGIPVGDIQK
     QEENQLRNLA NDLKAHVIGQ DKAVEKVARA IRRNRIGFNK SGRPIGSFLF VGPTGVGKTE
     LAKQLAKQMF GSENAMIRFD MSEYMEQYSV SKLIGSAPGY VGYEEAGQLT EQVRHNPYSL
     ILLDEIEKAH PDVLNLFLQI LDDGRLTDSQ GRTVSFKDTI IIMTSNAGQG IKNASVGFTA
     ENETESKESA RNNMSQFFKP EFLNRLDDVI EFNELTKPDL LKIVDLMLKN TNDMVKDQGL
     HIDVIQAAKD KLVEEGFNPA LGARPLRRTI QEEIEDNVAD FKLDHTDSKN LKADVVDDKI
     VISDENAAE
//