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Database: UniProt
Entry: A8YWE7_LACH4
LinkDB: A8YWE7_LACH4
Original site: A8YWE7_LACH4 
ID   A8YWE7_LACH4            Unreviewed;       887 AA.
AC   A8YWE7;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   24-JAN-2024, entry version 111.
DE   RecName: Full=DNA polymerase I {ECO:0000256|ARBA:ARBA00020311, ECO:0000256|RuleBase:RU004460};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417, ECO:0000256|RuleBase:RU004460};
GN   Name=polA {ECO:0000256|RuleBase:RU004460};
GN   OrderedLocusNames=lhv_1617 {ECO:0000313|EMBL:ABX27533.1};
OS   Lactobacillus helveticus (strain DPC 4571).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=405566 {ECO:0000313|EMBL:ABX27533.1, ECO:0000313|Proteomes:UP000000790};
RN   [1] {ECO:0000313|EMBL:ABX27533.1, ECO:0000313|Proteomes:UP000000790}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DPC 4571 {ECO:0000313|EMBL:ABX27533.1,
RC   ECO:0000313|Proteomes:UP000000790};
RX   PubMed=17993529; DOI=10.1128/JB.01295-07;
RA   Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K.,
RA   McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F.,
RA   Beresford T., Ross R.P.;
RT   "Genome sequence of Lactobacillus helveticus: an organism distinguished by
RT   selective gene loss and IS element expansion.";
RL   J. Bacteriol. 190:727-735(2008).
CC   -!- FUNCTION: In addition to polymerase activity, this DNA polymerase
CC       exhibits 5'-3' exonuclease activity. {ECO:0000256|RuleBase:RU004460}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632,
CC         ECO:0000256|RuleBase:RU004460};
CC   -!- SUBUNIT: Single-chain monomer with multiple functions.
CC       {ECO:0000256|ARBA:ARBA00011541, ECO:0000256|RuleBase:RU004460}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC       {ECO:0000256|ARBA:ARBA00007705, ECO:0000256|RuleBase:RU004460}.
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DR   EMBL; CP000517; ABX27533.1; -; Genomic_DNA.
DR   RefSeq; WP_012212131.1; NC_010080.1.
DR   AlphaFoldDB; A8YWE7; -.
DR   KEGG; lhe:lhv_1617; -.
DR   eggNOG; COG0258; Bacteria.
DR   eggNOG; COG0749; Bacteria.
DR   HOGENOM; CLU_004675_0_0_9; -.
DR   OMA; NRPPMPD; -.
DR   Proteomes; UP000000790; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd08637; DNA_pol_A_pol_I_C; 1.
DR   CDD; cd06140; DNA_polA_I_Bacillus_like_exo; 1.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   CDD; cd09859; PIN_53EXO; 1.
DR   Gene3D; 3.30.70.370; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR018320; DNA_polymerase_1.
DR   InterPro; IPR002298; DNA_polymerase_A.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   NCBIfam; TIGR00593; pola; 1.
DR   PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR   PANTHER; PTHR10133:SF27; DNA POLYMERASE NU; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   PRINTS; PR00868; DNAPOLI.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SMART; SM00482; POLAc; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU004460};
KW   DNA repair {ECO:0000256|RuleBase:RU004460};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|RuleBase:RU004460};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004460};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU004460}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU004460};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004460}.
FT   DOMAIN          4..267
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00475"
FT   DOMAIN          302..477
FT                   /note="3'-5' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00474"
FT   DOMAIN          643..851
FT                   /note="DNA-directed DNA polymerase family A palm"
FT                   /evidence="ECO:0000259|SMART:SM00482"
SQ   SEQUENCE   887 AA;  100813 MW;  9BE22A0D89DAA33F CRC64;
     MADEKLLLID GNSVAFRAFY ALYRQLESFK SPDGLHTNAI YAFKNMLDVL LKDVDPTHVL
     VAFDAGKVTF RTKMYGEYKG GRAKTPEELL EQMPYIQEML HDLGIKTYEL KNYEADDIIG
     TFAAKGEKAG FTTTIVTGDR DLTQLASDKT TVEVTKSGVS KLEAYTPEHM KEVNGVTPSE
     FIDMKALMGD NSDNYPGVEG IGPKTASNLI QEYGSVENLY DHIDEMKKSK RKERLIRDKE
     KAFLAKKLAT IDRDSPVTLD IDDIKRQPVD YEKLRQFYEK MNFRKFLADL NASGAGQDST
     EVEKVEYIVL NDDNVKDVKA TEADTIEFYL EMLGANYHLA PFVGFSLKIN DKIYVSRDVE
     LLEEDNIKHI LEDEKIKKNV FDLKRTMVAA HRLGIHTHGL DYDMLLASYL INNENNSNDL
     GEIAHLYGDY SVKTDLEVYG KGKSEHIPDD DDELFNHLAS KVNAIESLKK TLLEKLKDHE
     QDALFDTIEI PTARVLARME MNGMKVEAST LIQLQNEFAV KLKKLEDKIY GQAGEKFNLN
     SPKQLGHILF EKLGLPVIKK TKTGYSTSVE VLDQLKTQSP IVSKILDYRQ IAKIQSTYVK
     GLLDVIQPDG RVHTRYLQTL TATGRLSSVD PNLQNIPTRT EEGKQIRKAF VPSEPDGYIF
     SCDYSQVELR VLAHVSGDQN MQEAFKTGYD IHSHTAMKIF HLESPDEVTP LMRRHAKAVN
     FGIVYGISDY GLSKNLGISR KRAQEFIDNY FEQYPQIKDY MNKAVQEARD KGYAETIMHR
     RRYLPDIHAK KYTVRAFAER TAINSPIQGS AADIIKIAMI NMQKKLDELH LKTKMVIQVH
     DELIFDVPKD ELETIKKIVP EVMQSAVKLD VPLIADSGWG HNWYDAK
//
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