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Database: UniProt
Entry: A9CVG1_HOEPD
LinkDB: A9CVG1_HOEPD
Original site: A9CVG1_HOEPD 
ID   A9CVG1_HOEPD            Unreviewed;       530 AA.
AC   A9CVG1;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   24-JAN-2024, entry version 72.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN   ORFNames=HPDFL43_19292 {ECO:0000313|EMBL:EDQ35371.1};
OS   Hoeflea phototrophica (strain DSM 17068 / NCIMB 14078 / DFL-43).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Phyllobacteriaceae; Hoeflea.
OX   NCBI_TaxID=411684 {ECO:0000313|EMBL:EDQ35371.1, ECO:0000313|Proteomes:UP000004291};
RN   [1] {ECO:0000313|EMBL:EDQ35371.1, ECO:0000313|Proteomes:UP000004291}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DFL-43 {ECO:0000313|EMBL:EDQ35371.1,
RC   ECO:0000313|Proteomes:UP000004291};
RA   Wagner-Dobler I., Ferriera S., Johnson J., Kravitz S., Beeson K.,
RA   Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EDQ35371.1, ECO:0000313|Proteomes:UP000004291}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DFL-43 {ECO:0000313|EMBL:EDQ35371.1,
RC   ECO:0000313|Proteomes:UP000004291};
RA   Fiebig A.;
RL   Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00378,
CC         ECO:0000256|RuleBase:RU004355};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDQ35371.1}.
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DR   EMBL; ABIA03000001; EDQ35371.1; -; Genomic_DNA.
DR   RefSeq; WP_007199602.1; NZ_CM002917.1.
DR   AlphaFoldDB; A9CVG1; -.
DR   STRING; 411684.HPDFL43_19292; -.
DR   eggNOG; COG1570; Bacteria.
DR   HOGENOM; CLU_023625_3_1_5; -.
DR   OrthoDB; 9802795at2; -.
DR   Proteomes; UP000004291; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   NCBIfam; TIGR00237; xseA; 1.
DR   PANTHER; PTHR30008; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR   PANTHER; PTHR30008:SF0; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00378};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW   Rule:MF_00378};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00378};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00378};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004291}.
FT   DOMAIN          15..109
FT                   /note="OB-fold nucleic acid binding"
FT                   /evidence="ECO:0000259|Pfam:PF13742"
FT   DOMAIN          132..496
FT                   /note="Exonuclease VII large subunit C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02601"
FT   REGION          498..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   530 AA;  57740 MW;  D769A2D4E5E6539C CRC64;
     MSSLLDDSPT NAAEFTVSEL SGSIRRTVED AFGNVRVRGE ISGYRGPHSS GHAYFSLKDD
     RARIEAVIWK GVFSRLKHRP EEGLEVIATG KITTYAGSSK YQIVIESIEP AGAGALMALI
     EERRCKLAAE GLFDEARKQL LPYMPLVIGV VTSPTGAVIR DILHRIEDRF PVHVIVWPVR
     VQGDTSGNEV ANAITGFNAL APGGRIKRPD LIIVARGGGS LEDLWGFNDE AVVRAAAESD
     IPLISAVGHE TDWTLIDHAS DRRAPTPTGA AEMAVPVKAD LEAHLAGLAA RLKSAQSRML
     DRRREAVRGL TRALPTLDSV LALPRQRLDR SGQGLGQALQ LNTANRRRGF ERQAARITPI
     ALVSAIREKR QVLRDRATRA DRSLERRVEV LRTGLERHAL VLSAVPRRIT ETQTHARERL
     TGLGRRGETA LTQLIGQHKR ALGAQARMLK SLSYQSVLGR GYAVVRNQDR KLLSRAEQVQ
     SGEMIGVEFA DGEVSALVNG TGAEAPSSKP KKQTRTKANK TPEPGQGSLF
//
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