ID A9FVI2_SORC5 Unreviewed; 595 AA.
AC A9FVI2;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Pyruvate oxidase {ECO:0000313|EMBL:CAN92279.1};
DE EC=1.2.3.3 {ECO:0000313|EMBL:CAN92279.1};
GN OrderedLocusNames=sce2120 {ECO:0000313|EMBL:CAN92279.1};
OS Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So
OS ce56)).
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=448385 {ECO:0000313|EMBL:CAN92279.1, ECO:0000313|Proteomes:UP000002139};
RN [1] {ECO:0000313|EMBL:CAN92279.1, ECO:0000313|Proteomes:UP000002139}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=So ce56 {ECO:0000313|Proteomes:UP000002139};
RX PubMed=17965706; DOI=10.1038/nbt1354;
RA Schneiker S., Perlova O., Kaiser O., Gerth K., Alici A., Altmeyer M.O.,
RA Bartels D., Bekel T., Beyer S., Bode E., Bode H.B., Bolten C.J.,
RA Choudhuri J.V., Doss S., Elnakady Y.A., Frank B., Gaigalat L., Goesmann A.,
RA Groeger C., Gross F., Jelsbak L., Jelsbak L., Kalinowski J., Kegler C.,
RA Knauber T., Konietzny S., Kopp M., Krause L., Krug D., Linke B., Mahmud T.,
RA Martinez-Arias R., McHardy A.C., Merai M., Meyer F., Mormann S.,
RA Munoz-Dorado J., Perez J., Pradella S., Rachid S., Raddatz G., Rosenau F.,
RA Rueckert C., Sasse F., Scharfe M., Schuster S.C., Suen G.,
RA Treuner-Lange A., Velicer G.J., Vorholter F.-J., Weissman K.J., Welch R.D.,
RA Wenzel S.C., Whitworth D.E., Wilhelm S., Wittmann C., Bloecker H.,
RA Puehler A., Mueller R.;
RT "Complete genome sequence of the myxobacterium Sorangium cellulosum.";
RL Nat. Biotechnol. 25:1281-1289(2007).
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR EMBL; AM746676; CAN92279.1; -; Genomic_DNA.
DR RefSeq; WP_012234754.1; NC_010162.1.
DR AlphaFoldDB; A9FVI2; -.
DR STRING; 448385.sce2120; -.
DR KEGG; scl:sce2120; -.
DR eggNOG; COG0028; Bacteria.
DR HOGENOM; CLU_013748_3_0_7; -.
DR OrthoDB; 2254214at2; -.
DR BioCyc; SCEL448385:SCE_RS10900-MONOMER; -.
DR Proteomes; UP000002139; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0047112; F:pyruvate oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd02014; TPP_POX; 1.
DR CDD; cd07039; TPP_PYR_POX; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR047211; POXB-like.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR InterPro; IPR047212; TPP_POXB-like.
DR InterPro; IPR047210; TPP_PYR_POXB-like.
DR PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:CAN92279.1};
KW Pyruvate {ECO:0000313|EMBL:CAN92279.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002139};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 4..118
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 199..328
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 388..542
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 595 AA; 65387 MW; EADAB8A06245D9E4 CRC64;
MAQTVGEFLL RRLVAWGVRR VYAYPGDGIN GIVGAFHRVP DLRFIQVRHE EMAAFMACAH
AKFTGEVGVC LATSGPGAIH LLNGLYDAKL DHQPVVAIVG QQDRAALGGH YQQEVDLVTL
FKDVAHEYVQ MASSPAQMRH LIDRAMRIAK AERTVTCVIV PKDVQELDAV EQPPHAHGTV
HSGIGYSSPR VVPKEEDLRR AADVLNAGKR VAMLIGQGAL GAAPEIVRAA EILGCGVAKA
LLGKAALPDD LPWVTGAIGL LGTKPSWEMM ANCDTLFMVG SNFPYPEFLP EEGKARGVQI
DIDGRMLGLR YPMEVNLIGD CAETLRALIP YLKLKTDRSW RRKLEESVAD WWKVLEARAM
NDADPLNPQR VYWELSPRLP DGCILTADSG TSANWYARDI KIRAGMMASL SGTLATMGPA
MPYAVAAKFA FPDRPVVAMV GDGAMQMNGI NTLITVAKYW REWKDPRLVV LVLNNRDLNM
VTWELRAMSG DPKLEASQTL PDFPYAAYAE ALGLRGVRID RPDQCARTWD EAFRVDRPVV
VEAITDPEVP PLPPHITVKQ AAMLTSALLR GDPGGRGIVR QAYRDMIESW IPHRG
//
