ID A9G8Y7_SORC5 Unreviewed; 1319 AA.
AC A9G8Y7;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN OrderedLocusNames=sce8916 {ECO:0000313|EMBL:CAN99088.1};
OS Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So
OS ce56)).
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=448385 {ECO:0000313|EMBL:CAN99088.1, ECO:0000313|Proteomes:UP000002139};
RN [1] {ECO:0000313|EMBL:CAN99088.1, ECO:0000313|Proteomes:UP000002139}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=So ce56 {ECO:0000313|Proteomes:UP000002139};
RX PubMed=17965706; DOI=10.1038/nbt1354;
RA Schneiker S., Perlova O., Kaiser O., Gerth K., Alici A., Altmeyer M.O.,
RA Bartels D., Bekel T., Beyer S., Bode E., Bode H.B., Bolten C.J.,
RA Choudhuri J.V., Doss S., Elnakady Y.A., Frank B., Gaigalat L., Goesmann A.,
RA Groeger C., Gross F., Jelsbak L., Jelsbak L., Kalinowski J., Kegler C.,
RA Knauber T., Konietzny S., Kopp M., Krause L., Krug D., Linke B., Mahmud T.,
RA Martinez-Arias R., McHardy A.C., Merai M., Meyer F., Mormann S.,
RA Munoz-Dorado J., Perez J., Pradella S., Rachid S., Raddatz G., Rosenau F.,
RA Rueckert C., Sasse F., Scharfe M., Schuster S.C., Suen G.,
RA Treuner-Lange A., Velicer G.J., Vorholter F.-J., Weissman K.J., Welch R.D.,
RA Wenzel S.C., Whitworth D.E., Wilhelm S., Wittmann C., Bloecker H.,
RA Puehler A., Mueller R.;
RT "Complete genome sequence of the myxobacterium Sorangium cellulosum.";
RL Nat. Biotechnol. 25:1281-1289(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; AM746676; CAN99088.1; -; Genomic_DNA.
DR STRING; 448385.sce8916; -.
DR KEGG; scl:sce8916; -.
DR eggNOG; COG0515; Bacteria.
DR eggNOG; COG2909; Bacteria.
DR HOGENOM; CLU_006367_0_0_7; -.
DR Proteomes; UP000002139; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR PANTHER; PTHR43289:SF6; SERINE_THREONINE-PROTEIN KINASE NEKL-3; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CAN99088.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002139};
KW Transferase {ECO:0000313|EMBL:CAN99088.1}.
FT DOMAIN 17..274
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 1319 AA; 142639 MW; 46034C8D84106A18 CRC64;
MILAVPMKPG DIVADRFLIE RLAGSGGMGS VYRALDRHTG ETAALKVMSG RGLEHGERFA
REAQVLAELR HPGIVRYIAQ GATESGEPWL ALEWLEGESL GDRLRRRGLT IAESVTLGLR
VAEALAEAHR HNVVHRDLKP SNLYLVDKSV EQVKLLDFGI ARLTSLAPLT MTGVVMGTPF
YMAPEQARGE RDVGTQADVF ALGCVLFHCL TGRPPFVGDD IHTALLRVVL DEAPRLRDLR
ADVPENVDIA VARMLAKAPA DRPANGAAVA LELLRVGEIK STPPAPASRR ASALTTGERR
TLCLMLARMG APEAPSWQGP TMPMTLPMTM PLARTVPEDE VKRVASRFGG ALQTLADGLL
LITLEGRGLI TDQAARAARC ALEVRDLLPG VQMALVAGRG SADDQLPMGP TIDRAVRLLD
RADGGSIRLD EVMAGLLDAR FEVGGDATGL VLRAERDLVE AARTLLGRTT PFVGRDHELA
ILDAVLDECL SEPTARAVLI TAPAGLGKSR LRYEFLRRVE ERKERVQVWL GHADPMSAGS
PFGMLRQMLR REAGLSGGEP QEVREQRLRA RVGRYLSGAD LDRVTEFLGE VARIRFSDEG
RVELRAARSD PMLMGDQIRR AFEDFVLAEC RAEPVLLVLE DLQWGDVPTV KLIDAALALR
DQPLMVLALA RPEVETVFPK VWVSRGVQEL RLREIGRRGS ERLVREVLGD AVTPDVCARL
CERAGGNAFY LEELIRAAAS GRTEALPETV LSMVQARLES LDGEARRVLR AASVFGQKFW
RGGLMALLGG ERRAPQVDGW LAVLVDRELI ARRGEGKFRS EDEYAFRHAL VREAAYATLT
DADRALGHLL AGEWLDAAGE RDAALLADHF ERGGDAERAV VWFRRAAEQA LGANDFRAAI
QRAEQGAASA DVDGEFFAAL RLVQAEAHKW LGEASQAERC AVMAMRGFPR KSALWYAAAG
EAASMRVRLG MGDRLADLVE ELRGAGPGSG DRGSWVDVAE ATGASVSALA RIAGSLLHGG
QYAAAEEIVQ ELARVAMPLA ERDAAVAARI HALRASRALC YGDPAASLAC TEQSIPAYLQ
TGDLRNACLS RVNAAHCLLQ LGVYGRAEAE LRDALAEAGR LGLYNVAAFA KQNQGLLWIQ
QGDLGAARAA TAEAIDAFVA QANRRQEARS RAYLAAILTR LGDLDAADNE AGAAVAMLAH
VPTLQAHALS VRARVLLEQG RAAEALEAAR RGLGLLVSVG GTEEGEAQIR LVYAESLRAC
GHHEAAREAI TVAMQRLVAR AQWIQDPGRR QSFCQAVPEN AKTFALAALW QQEAEPTLQ
//
