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Database: UniProt
Entry: A9GHT5_SORC5
LinkDB: A9GHT5_SORC5
Original site: A9GHT5_SORC5 
ID   A9GHT5_SORC5            Unreviewed;       471 AA.
AC   A9GHT5;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   23-MAY-2018, entry version 86.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:CAN90157.1};
GN   OrderedLocusNames=sce0001 {ECO:0000313|EMBL:CAN90157.1};
OS   Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain
OS   So ce56)).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Sorangiineae; Polyangiaceae; Sorangium.
OX   NCBI_TaxID=448385 {ECO:0000313|EMBL:CAN90157.1, ECO:0000313|Proteomes:UP000002139};
RN   [1] {ECO:0000313|EMBL:CAN90157.1, ECO:0000313|Proteomes:UP000002139}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=So ce56 {ECO:0000313|Proteomes:UP000002139};
RX   PubMed=17965706; DOI=10.1038/nbt1354;
RA   Schneiker S., Perlova O., Kaiser O., Gerth K., Alici A.,
RA   Altmeyer M.O., Bartels D., Bekel T., Beyer S., Bode E., Bode H.B.,
RA   Bolten C.J., Choudhuri J.V., Doss S., Elnakady Y.A., Frank B.,
RA   Gaigalat L., Goesmann A., Groeger C., Gross F., Jelsbak L.,
RA   Jelsbak L., Kalinowski J., Kegler C., Knauber T., Konietzny S.,
RA   Kopp M., Krause L., Krug D., Linke B., Mahmud T., Martinez-Arias R.,
RA   McHardy A.C., Merai M., Meyer F., Mormann S., Munoz-Dorado J.,
RA   Perez J., Pradella S., Rachid S., Raddatz G., Rosenau F., Rueckert C.,
RA   Sasse F., Scharfe M., Schuster S.C., Suen G., Treuner-Lange A.,
RA   Velicer G.J., Vorholter F.-J., Weissman K.J., Welch R.D., Wenzel S.C.,
RA   Whitworth D.E., Wilhelm S., Wittmann C., Bloecker H., Puehler A.,
RA   Mueller R.;
RT   "Complete genome sequence of the myxobacterium Sorangium cellulosum.";
RL   Nat. Biotechnol. 25:1281-1289(2007).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00747961}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; AM746676; CAN90157.1; -; Genomic_DNA.
DR   RefSeq; WP_012232635.1; NC_010162.1.
DR   ProteinModelPortal; A9GHT5; -.
DR   STRING; 448385.sce0001; -.
DR   EnsemblBacteria; CAN90157; CAN90157; sce0001.
DR   KEGG; scl:sce0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235659; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   BioCyc; SCEL448385:G1GJQ-1-MONOMER; -.
DR   Proteomes; UP000002139; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002139};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00747973};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00748008};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002139}.
FT   DOMAIN      166    296       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      378    447       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     174    181       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   471 AA;  53079 MW;  A079D39B56A1D8C1 CRC64;
     MTIPKHEPRE VFDRAIEHTR ALSPATFDQW FGGVQFDDLT DGVLTLRVQN EFVLEWVRDN
     FLPALTDKIR ELTGWSVQVA WTVDQNLDAP IAQRVELTPV RPRALVVRPT SAAPAPAPRP
     EPALRRVPSM PDDLNPKHTF ASFVVGPSNQ LAHAAAIAAA GGGGRRYNPL FICGGTGLGK
     THLMHAIAHR VFEGRPDARI IYVSAEKFTN DFITAIQHHR MDEFRTRYRS SCDVLLVDDI
     QFLAGREQTQ EEFFHTFNAL HTLDRQIVVT SDKYPQNLER MEERLVSRFS WGLVADIQVP
     ELETRVAIVR NKAALEGIAL TDDVALYLAQ MVRSNVRELE GTLIRLAAKS SLTGRPVDLP
     FARAEITATS PPRAQMMSVE DIQRAVCHHF HLRSIDLTSK DRHKSVAFAR HVAMYLCKQR
     LKCSFPEIGR AFGNRDHTTV MSAVRKIEAQ RDSDPQVRAH LEALEKKLAD E
//
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