ID A9GXX4_SORC5 Unreviewed; 581 AA.
AC A9GXX4;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Adenylate cyclase {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=sce6986 {ECO:0000313|EMBL:CAN97155.1};
OS Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So
OS ce56)).
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=448385 {ECO:0000313|EMBL:CAN97155.1, ECO:0000313|Proteomes:UP000002139};
RN [1] {ECO:0000313|EMBL:CAN97155.1, ECO:0000313|Proteomes:UP000002139}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=So ce56 {ECO:0000313|Proteomes:UP000002139};
RX PubMed=17965706; DOI=10.1038/nbt1354;
RA Schneiker S., Perlova O., Kaiser O., Gerth K., Alici A., Altmeyer M.O.,
RA Bartels D., Bekel T., Beyer S., Bode E., Bode H.B., Bolten C.J.,
RA Choudhuri J.V., Doss S., Elnakady Y.A., Frank B., Gaigalat L., Goesmann A.,
RA Groeger C., Gross F., Jelsbak L., Jelsbak L., Kalinowski J., Kegler C.,
RA Knauber T., Konietzny S., Kopp M., Krause L., Krug D., Linke B., Mahmud T.,
RA Martinez-Arias R., McHardy A.C., Merai M., Meyer F., Mormann S.,
RA Munoz-Dorado J., Perez J., Pradella S., Rachid S., Raddatz G., Rosenau F.,
RA Rueckert C., Sasse F., Scharfe M., Schuster S.C., Suen G.,
RA Treuner-Lange A., Velicer G.J., Vorholter F.-J., Weissman K.J., Welch R.D.,
RA Wenzel S.C., Whitworth D.E., Wilhelm S., Wittmann C., Bloecker H.,
RA Puehler A., Mueller R.;
RT "Complete genome sequence of the myxobacterium Sorangium cellulosum.";
RL Nat. Biotechnol. 25:1281-1289(2007).
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
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DR EMBL; AM746676; CAN97155.1; -; Genomic_DNA.
DR AlphaFoldDB; A9GXX4; -.
DR STRING; 448385.sce6986; -.
DR KEGG; scl:sce6986; -.
DR eggNOG; COG2114; Bacteria.
DR HOGENOM; CLU_469205_0_0_7; -.
DR BioCyc; SCEL448385:SCE_RS35845-MONOMER; -.
DR Proteomes; UP000002139; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002139};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 293..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 316..368
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 400..532
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 581 AA; 62945 MW; 839E655BAA83DE53 CRC64;
MSTRCPPEAD FALMKAFMFR LSTVRAKLTV LVALSSLATL AALPVLSWVM HRQLLAQISE
RVPQAIRNFR LELRQQQRAI SATSRQASRA RELVEGLRLR NESDVGTALE AVVAAHPNVA
MVAFDELGNR VAARGLDAPP PSTDEVPGLT EGLSGLAEMD DLRDVLVHGC DGQQGSPPAY
MIAQHARSDA GSLLACIPID HTYFDEAATR LGVEIALVDP AGKRITGTAR FPTELLQGAV
IGDETHPTIV EHASSLWALS RFAPRSLRGK AGDFSIVMAL DVSDVRNIVR QNLMFAAGVL
TLAALFSLLL GARLATTMSR ALSRVNVALK HLEQQRYVHV EAVKTGDELE DLATGFNSMV
DGLKERDKLR STFGKYMTES VLEHLLAGKV QLGGETLTVS ILFCDIRSFT TISERMNAHE
LVGLLNEYFT EMVAIILDEG GVVDKYIGDA IMAVFGAPVP RPNDAVRAVR AAIRMRAALE
RFNERLARRG IPALKTGVGI HTGEVVAGNI GSEARMEYTV IGDAVNLASR LESATKELGV
SVLLSEDTHL LVKDVFNTRP ISEITVKGRV KPVMTYAVAD L
//
