ID A9J0T3_VACCA Unreviewed; 493 AA.
AC A9J0T3;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Transcription termination factor {ECO:0000313|EMBL:CAM58309.1};
GN ORFNames=CVA145 {ECO:0000313|EMBL:CAM58309.1};
OS Vaccinia virus (strain Ankara) (VACV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX NCBI_TaxID=126794 {ECO:0000313|EMBL:CAM58309.1, ECO:0000313|Proteomes:UP000136916};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:CAM58309.1, ECO:0000313|Proteomes:UP000136916}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chorioallantois vaccinia virus Ankara
RC {ECO:0000313|EMBL:CAM58309.1};
RX PubMed=18024893; DOI=10.1099/vir.0.83156-0;
RA Meisinger-Henschel C., Schmidt M., Lukassen S., Linke B., Krause L.,
RA Konietzny S., Goesmann A., Howley P., Chaplin P., Suter M., Hausmann J.;
RT "Genomic sequence of chorioallantois vaccinia virus Ankara, the ancestor of
RT modified vaccinia virus Ankara.";
RL J. Gen. Virol. 88:3249-3259(2007).
CC -!- FUNCTION: DNA helicase which seems to act as a postreplicative
CC transcription termination factor. Involved in ATP-dependent release of
CC nascent RNA. Forms a stable complex with single-stranded DNA, and to a
CC lesser extent RNA. {ECO:0000256|ARBA:ARBA00037581}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the helicase family. Poxviruses subfamily.
CC {ECO:0000256|ARBA:ARBA00038498}.
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DR EMBL; AM501482; CAM58309.1; -; Genomic_DNA.
DR Proteomes; UP000136916; Genome.
DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18785; SF2_C; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Late protein {ECO:0000256|ARBA:ARBA00022921};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Virion {ECO:0000256|ARBA:ARBA00022844}.
FT DOMAIN 100..256
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
SQ SEQUENCE 493 AA; 56771 MW; E63618A94DF4EE6E CRC64;
MSLLKMEYNL YAELKKMTCG QPLSLFNEDG DFVEVEPGSS FKFLIPKGFY ASPSVKTSLV
FETLTTTDNK ITSINPTNAP KLYPLQRKVV SEVVSNMRKM IELKRPLYIT LHLACGFGKT
ITTCYLMATH GRKTVICVPN KMLIHQWKTQ VEAVGLEHKI SIDGVSSLLK ELKTQSPDVL
IVVSRHLTND AFCKYINKHY DLFILDESHT YNLMNNTAVT RFLAYYPPMM CYFLTATPRP
SNRIYCNSII NIAKLSDLKK TIYAVDSFFE PYSTDNIRHM IKRLDGPSNK YHIYTEKLLS
VDEPRNQLIL DTLVEEFKSG TINRILVITK LREHMVFFYK RLLDFFGSEV VFIGDAQNRR
TPDMVKSIKE LNRFIFVSTL FYSGTGLDIP SLDSLFICSA VINNMQIEQL LGRVCRETEL
LDRTVYVFPS TSIKEIKYMI GNFVQRIISL SVDKLGFKQK SYRKHQESDP TSVCTTSSRE
ERVLNRIFNS QNR
//
