ID A9MK06_SALAR Unreviewed; 643 AA.
AC A9MK06;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Heme lyase CcmF/NrfE family subunit {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=SARI_00641 {ECO:0000313|EMBL:ABX20565.1};
OS Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=41514 {ECO:0000313|EMBL:ABX20565.1, ECO:0000313|Proteomes:UP000002084};
RN [1] {ECO:0000313|EMBL:ABX20565.1, ECO:0000313|Proteomes:UP000002084}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-731 / CDC346-86 / RSK2980
RC {ECO:0000313|Proteomes:UP000002084};
RG The Salmonella enterica serovar Arizonae Genome Sequencing Project;
RA McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W.,
RA Johnson M., Thiruvilangam P., Wilson R.;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the biogenesis of c-type cytochromes. Possible
CC subunit of a heme lyase. {ECO:0000256|ARBA:ARBA00037230}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
CC {ECO:0000256|ARBA:ARBA00009186}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000880; ABX20565.1; -; Genomic_DNA.
DR AlphaFoldDB; A9MK06; -.
DR STRING; 41514.SARI_00641; -.
DR KEGG; ses:SARI_00641; -.
DR HOGENOM; CLU_015041_3_0_6; -.
DR Proteomes; UP000002084; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR InterPro; IPR032523; CcmF_C.
DR InterPro; IPR002541; Cyt_c_assembly.
DR InterPro; IPR003567; Cyt_c_biogenesis.
DR InterPro; IPR003568; Cyt_c_biogenesis_CcmF.
DR NCBIfam; TIGR00353; nrfE; 1.
DR PANTHER; PTHR43653; CYTOCHROME C ASSEMBLY PROTEIN-RELATED; 1.
DR PANTHER; PTHR43653:SF1; CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCMF; 1.
DR Pfam; PF16327; CcmF_C; 1.
DR Pfam; PF01578; Cytochrom_C_asm; 1.
DR PRINTS; PR01410; CCBIOGENESIS.
DR PRINTS; PR01411; CCMFBIOGNSIS.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytochrome c-type biogenesis {ECO:0000256|ARBA:ARBA00022748};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002084};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 41..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 89..296
FT /note="Cytochrome c assembly protein"
FT /evidence="ECO:0000259|Pfam:PF01578"
FT DOMAIN 316..630
FT /note="Cytochrome c-type biogenesis protein CcmF C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF16327"
SQ SEQUENCE 643 AA; 70480 MW; 744391D9707AAFB8 CRC64;
MMPEIGNALL CLALGVALLL SVYPLWGAAR GDARMMASSG VFAWLLFLCV AGAFFVLAHA
FVVNDFTVAY VAGNSNTQLP VWYRVAATWG AHEGSLLLWV LLMSGWTLAV AVFSRPVPVD
IVARVLAVMG MVSAGFLVFI LFTSNPFART LPDFPVEGRD LNPLLQDPGL IFHPPLLYMG
YVGFSVAFAF AIAALLCGRL DSAFARFSRP WTLAAWVFLT LGIVLGSAWA YYELGWGGWW
FWDPVENASF MPWLAGTALL HSLAVTEQRA SFKAWTLLLS ICAFSLCLLG TFLVRSGVLV
SVHAFASDPA RGMFILAFMV LVTGGSLLLF AVRGHRVRSR VNNALWSRES LLLGNNVLLM
AAMLVVLLGT LLPLVHKQLG LGSISIGEPF FNTMFTWLMA PFALLLGVGP LVRWGRDRPR
KIRNLLLVAF ITTLLLSVLL PWLLQDRIAA MTVAGMAMAC WIAVLAVAEA VQRVSRGTRT
SFSYWGMVAA HLGLAVTITG IAFSQNYSIE RDVRMRAGDS VTIHDYRFTF REVRDITGPN
YRGGVAIIGV TRDGAPEAVL HAEKRLYNTS RMVMTEAAID GGLTRDLYAA LGEELDNGAW
AVRLYYKPFV RWIWAGGLLM ALGGLLCLAD PRYRRRKPLP EAG
//
