ID   A9MRW0_SALAR            Unreviewed;       277 AA.
AC   A9MRW0;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   RecName: Full=Adenosine deaminase {ECO:0000256|ARBA:ARBA00018099};
DE            EC=3.5.4.4 {ECO:0000256|ARBA:ARBA00012784};
GN   OrderedLocusNames=SARI_01517 {ECO:0000313|EMBL:ABX21413.1};
OS   Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=41514 {ECO:0000313|EMBL:ABX21413.1, ECO:0000313|Proteomes:UP000002084};
RN   [1] {ECO:0000313|EMBL:ABX21413.1, ECO:0000313|Proteomes:UP000002084}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-731 / CDC346-86 / RSK2980
RC   {ECO:0000313|Proteomes:UP000002084};
RG   The Salmonella enterica serovar Arizonae Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA   Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W.,
RA   Johnson M., Thiruvilangam P., Wilson R.;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000880; ABX21413.1; -; Genomic_DNA.
DR   AlphaFoldDB; A9MRW0; -.
DR   STRING; 41514.SARI_01517; -.
DR   KEGG; ses:SARI_01517; -.
DR   HOGENOM; CLU_039228_0_2_6; -.
DR   Proteomes; UP000002084; Chromosome.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProt.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR   PANTHER; PTHR11409:SF43; ADENOSINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002084}.
FT   DOMAIN          2..276
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   277 AA;  29975 MW;  DC41E984B29A36EE CRC64;
     MSFLSKLDWG VKVLASLDAC RRVAFENIED AARNGLHYVE LRFSPGYMAM AHQLPVTGVV
     EAVIDGVRDG CNTFGVEARL IGIMSRTFGE AACSQELNAL LAHREKITAL DLAGDELGFP
     GSLFLSHFNR ARDAGWHITV HAGEAAGPES IWQAIRELGA ERIGHGVKAV EDRALMDFLA
     QQRIGIESCL TSNIQTSTVA SLADHPLKTF LEHGVLASLN TDDPAVQGVD IIHEYHIAAP
     AAGLSREQIR QAQINGLEIA FLSDTEKRAL REKVAAA
//