ID A9NG22_ACHLI Unreviewed; 441 AA.
AC A9NG22;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=K+/H+ antiporter, NEM-activated {ECO:0000313|EMBL:ABX81302.1};
GN Name=kefB {ECO:0000313|EMBL:ABX81302.1};
GN OrderedLocusNames=ACL_0686 {ECO:0000313|EMBL:ABX81302.1};
OS Acholeplasma laidlawii (strain PG-8A).
OC Bacteria; Mycoplasmatota; Mollicutes; Acholeplasmatales;
OC Acholeplasmataceae; Acholeplasma.
OX NCBI_TaxID=441768 {ECO:0000313|EMBL:ABX81302.1, ECO:0000313|Proteomes:UP000008558};
RN [1] {ECO:0000313|EMBL:ABX81302.1, ECO:0000313|Proteomes:UP000008558}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PG-8A {ECO:0000313|EMBL:ABX81302.1,
RC ECO:0000313|Proteomes:UP000008558};
RX PubMed=21784942; DOI=10.1128/JB.05059-11;
RA Lazarev V.N., Levitskii S.A., Basovskii Y.I., Chukin M.M., Akopian T.A.,
RA Vereshchagin V.V., Kostrjukova E.S., Kovaleva G.Y., Kazanov M.D.,
RA Malko D.B., Vitreschak A.G., Sernova N.V., Gelfand M.S., Demina I.A.,
RA Serebryakova M.V., Galyamina M.A., Vtyurin N.N., Rogov S.I., Alexeev D.G.,
RA Ladygina V.G., Govorun V.M.;
RT "Complete genome and proteome of Acholeplasma laidlawii.";
RL J. Bacteriol. 193:4943-4953(2011).
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DR EMBL; CP000896; ABX81302.1; -; Genomic_DNA.
DR RefSeq; WP_012242633.1; NC_010163.1.
DR AlphaFoldDB; A9NG22; -.
DR STRING; 441768.ACL_0686; -.
DR GeneID; 66293680; -.
DR KEGG; acl:ACL_0686; -.
DR eggNOG; COG0475; Bacteria.
DR HOGENOM; CLU_031031_2_1_14; -.
DR Proteomes; UP000008558; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR43021; NA(+)/H(+) ANTIPORTER-RELATED; 1.
DR PANTHER; PTHR43021:SF2; NA_H_EXCHANGER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008558};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 35..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..405
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 441 AA; 47369 MW; F4300A55A54D023D CRC64;
MEIGLLLTKV AVILFVGFIG SLIARKFKLP NVSGYLVLGL LIGPSLGLIF PGYEGFITSS
DQDVFGFISE LALAFIAFSI GSEFAIKRVK KMGKEISVIT LLEVLGAVSL VFIAMLFIPK
PDSMSSGYNP FSNSSIAFAL ILASMSAATA PAATLMVMRQ YRANGPVSKA IVPITALDDI
FGIIIFGFFL SIAQLLLPQG DPLPVWLMIS KPFIEVFGSL IIGLIIGIAL SYGAKKFDKI
SDDIQVLSLI AIFATVGGLT LMNHYMSDFG ISFSPLLANI MVGSVIANIA LKPNRTFQSI
NDLATPFYII FFTLAGASLD LGILRQDYLI LIIAATYIIA RGSGKILGTM AGAQMVNSHP
NVKKYLGFAL LPQGGVSIGL LTIVAVQMTQ LYPIIAAVIM LSVLVYETMG PVFAKYSLTK
SDELYGLDKL NESMFEEDTE N
//
