ID A9NJG3_SALSA Unreviewed; 1147 AA.
AC A9NJG3;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=Na/K/2Cl co-transporter {ECO:0000313|EMBL:ABI74746.1, ECO:0000313|RefSeq:NP_001117155.1};
GN Name=NKCC1a {ECO:0000313|EMBL:ABI74746.1};
GN Synonyms=nkcc1a {ECO:0000313|RefSeq:NP_001117155.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ABI74746.1};
RN [1] {ECO:0000313|EMBL:ABI74746.1}
RP NUCLEOTIDE SEQUENCE.
RX AGRICOLA=IND43991829;
RA Mackie P.M., Gharbi K., Ballantyne J.S., McCormick S.D., Wright P.A.;
RT "Na+/K+/2Cl- cotransporter and CFTR gill expression after seawater transfer
RT in smolts (0+) of different Atlantic salmon (Salmo salar) families.";
RL Aquaculture 272:625-635(2007).
RN [2] {ECO:0000313|RefSeq:NP_001117155.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; DQ864492; ABI74746.1; -; mRNA.
DR RefSeq; NP_001117155.1; NM_001123683.1.
DR Ensembl; ENSSSAT00000128181; ENSSSAP00000093883; ENSSSAG00000071196.
DR GeneID; 100136908; -.
DR KEGG; sasa:100136908; -.
DR CTD; 6558; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000087266; Chromosome ssa01.
DR Bgee; ENSSSAG00000071196; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IDA:AgBase.
DR GO; GO:0005737; C:cytoplasm; IDA:AgBase.
DR GO; GO:0016020; C:membrane; IDA:AgBase.
DR GO; GO:0008511; F:sodium:potassium:chloride symporter activity; IDA:AgBase.
DR GO; GO:0015293; F:symporter activity; IDA:AgBase.
DR GO; GO:0042538; P:hyperosmotic salinity response; IDA:AgBase.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR002444; NKCC1.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF58; SOLUTE CARRIER FAMILY 12 MEMBER 2; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
DR PRINTS; PR01208; NAKCLTRSPRT1.
PE 2: Evidence at transcript level;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 245..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 129..182
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 217..724
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 733..1147
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..927
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1147 AA; 125556 MW; 7F83C8AE26EA7BEF CRC64;
MSAPSSLPPA QGENPVPENE GLAVDTGLKP AGPTPSSSRF QVDLVAEAAG AADKTLASGD
KGAPAPEGSE PAAGGEEAKG RFRVVNFVDP SGASPPEAVP AEGFQNGDTV MSEGSLHSST
GGQHHYHYDT HTNTYYLRTF GHNTIDAVPN IDFYRQTAAP LGDKLIRPTL SELHDELDKE
PFEDGFANGD ELTPAEEAAA KEASEPKGAV KFGWIKGVLV RCMLNIWGVM LFIRMSWIVG
QAGIVLSCVI VLMATVVTTI TGLSTSAIAT NGFVRGGGAY YLISRSLGPE FGGSIGLIFA
FANAVAVAMY VVGFAETVVE LLVSVDCIMT DEINDIRIVG TITVILLLGI SVAGMEWEAK
AQIFLLVVLI TAIFNYFIGS FIPLQSKESQ GFFGYDSGIM MENMGPDFRG TESFFSVFAI
FFPAATGILA GANISGDLSD PQLAIPRGTL LAILITGIVY LGVAISTGSC IVRDATGNDN
DTHSAQIMAN CTDAACKFGY DFSSCKSDNG LYNCRYGLQN DFQVMSIVSG FGPIITAGIF
SATLSSALAS LVSAPKVFQA LCKDNIYPGL EMFAKGYGKN NEPLRGYILT FCIALAFILI
AQLNVIAPII SNFFLASYAL INFSVFHASL ANSPGWRPSF KYYNMWVSLA GAVLCCVVMF
VINWWAALMT DVIVLGLYIY VSYKKPDVNW GSSTQALTYH QALTHSLHLS SVEDHIKNFR
PQCLVMTGYP NSRPALLHLV HAFTKNVGLM ICGHVRTGSR RPNFKELSND QTRYQRWLMK
NETKAFYTPV FAEDIREGTQ YLLQAAGLGR LRPNTLVIGF KNDWKDGDMM NVETYIQMIH
DAFDYQYGAV VLRLKEGLDV SHISEQDDLL SSQEKTSGMK DVVVSIDMKD SDGDSSKPSS
KATSVQNSPA IQKGDDDERK AATKPLLRKE KSPQMLNVAD QRLLDASQLF KRKQGKGTVD
VWWLFDDGGL TLLIPYLLTN KKKWNDCKIR VFIGGKINRI DHDRRAMATL LSKFRIDFSD
INVLGDINTK PKKENVTAFE EMIEPYRLKE DDMEQDTAEA LKASEPWRIT DNELELYRAK
TNRQIRLNEL LKEHSSTANL IVMSMPLARK GAVSSALYMS WLETLSKDLP PLLLVRGNHQ
SVLTFYS
//