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Database: UniProt
Entry: A9NJG3_SALSA
LinkDB: A9NJG3_SALSA
Original site: A9NJG3_SALSA 
ID   A9NJG3_SALSA            Unreviewed;      1147 AA.
AC   A9NJG3;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   24-JAN-2024, entry version 59.
DE   SubName: Full=Na/K/2Cl co-transporter {ECO:0000313|EMBL:ABI74746.1, ECO:0000313|RefSeq:NP_001117155.1};
GN   Name=NKCC1a {ECO:0000313|EMBL:ABI74746.1};
GN   Synonyms=nkcc1a {ECO:0000313|RefSeq:NP_001117155.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|EMBL:ABI74746.1};
RN   [1] {ECO:0000313|EMBL:ABI74746.1}
RP   NUCLEOTIDE SEQUENCE.
RX   AGRICOLA=IND43991829;
RA   Mackie P.M., Gharbi K., Ballantyne J.S., McCormick S.D., Wright P.A.;
RT   "Na+/K+/2Cl- cotransporter and CFTR gill expression after seawater transfer
RT   in smolts (0+) of different Atlantic salmon (Salmo salar) families.";
RL   Aquaculture 272:625-635(2007).
RN   [2] {ECO:0000313|RefSeq:NP_001117155.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC         K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC         ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC         Evidence={ECO:0000256|ARBA:ARBA00034631};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC         Evidence={ECO:0000256|ARBA:ARBA00034631};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
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DR   EMBL; DQ864492; ABI74746.1; -; mRNA.
DR   RefSeq; NP_001117155.1; NM_001123683.1.
DR   Ensembl; ENSSSAT00000128181; ENSSSAP00000093883; ENSSSAG00000071196.
DR   GeneID; 100136908; -.
DR   KEGG; sasa:100136908; -.
DR   CTD; 6558; -.
DR   OrthoDB; 5490251at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa01.
DR   Bgee; ENSSSAG00000071196; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR   GO; GO:0016323; C:basolateral plasma membrane; IDA:AgBase.
DR   GO; GO:0005737; C:cytoplasm; IDA:AgBase.
DR   GO; GO:0016020; C:membrane; IDA:AgBase.
DR   GO; GO:0008511; F:sodium:potassium:chloride symporter activity; IDA:AgBase.
DR   GO; GO:0015293; F:symporter activity; IDA:AgBase.
DR   GO; GO:0042538; P:hyperosmotic salinity response; IDA:AgBase.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR013612; AA_permease_N.
DR   InterPro; IPR002444; NKCC1.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR002443; SLC12A1/SLC12A2.
DR   InterPro; IPR004842; SLC12A_fam.
DR   NCBIfam; TIGR00930; 2a30; 1.
DR   PANTHER; PTHR11827:SF58; SOLUTE CARRIER FAMILY 12 MEMBER 2; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF08403; AA_permease_N; 1.
DR   Pfam; PF03522; SLC12; 1.
DR   PRINTS; PR01207; NAKCLTRNSPRT.
DR   PRINTS; PR01208; NAKCLTRSPRT1.
PE   2: Evidence at transcript level;
KW   Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        245..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        294..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        336..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        361..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        414..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        444..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        584..603
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        609..630
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        642..666
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          129..182
FT                   /note="Amino acid permease N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08403"
FT   DOMAIN          217..724
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          733..1147
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   REGION          1..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          888..931
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        897..911
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        912..927
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1147 AA;  125556 MW;  7F83C8AE26EA7BEF CRC64;
     MSAPSSLPPA QGENPVPENE GLAVDTGLKP AGPTPSSSRF QVDLVAEAAG AADKTLASGD
     KGAPAPEGSE PAAGGEEAKG RFRVVNFVDP SGASPPEAVP AEGFQNGDTV MSEGSLHSST
     GGQHHYHYDT HTNTYYLRTF GHNTIDAVPN IDFYRQTAAP LGDKLIRPTL SELHDELDKE
     PFEDGFANGD ELTPAEEAAA KEASEPKGAV KFGWIKGVLV RCMLNIWGVM LFIRMSWIVG
     QAGIVLSCVI VLMATVVTTI TGLSTSAIAT NGFVRGGGAY YLISRSLGPE FGGSIGLIFA
     FANAVAVAMY VVGFAETVVE LLVSVDCIMT DEINDIRIVG TITVILLLGI SVAGMEWEAK
     AQIFLLVVLI TAIFNYFIGS FIPLQSKESQ GFFGYDSGIM MENMGPDFRG TESFFSVFAI
     FFPAATGILA GANISGDLSD PQLAIPRGTL LAILITGIVY LGVAISTGSC IVRDATGNDN
     DTHSAQIMAN CTDAACKFGY DFSSCKSDNG LYNCRYGLQN DFQVMSIVSG FGPIITAGIF
     SATLSSALAS LVSAPKVFQA LCKDNIYPGL EMFAKGYGKN NEPLRGYILT FCIALAFILI
     AQLNVIAPII SNFFLASYAL INFSVFHASL ANSPGWRPSF KYYNMWVSLA GAVLCCVVMF
     VINWWAALMT DVIVLGLYIY VSYKKPDVNW GSSTQALTYH QALTHSLHLS SVEDHIKNFR
     PQCLVMTGYP NSRPALLHLV HAFTKNVGLM ICGHVRTGSR RPNFKELSND QTRYQRWLMK
     NETKAFYTPV FAEDIREGTQ YLLQAAGLGR LRPNTLVIGF KNDWKDGDMM NVETYIQMIH
     DAFDYQYGAV VLRLKEGLDV SHISEQDDLL SSQEKTSGMK DVVVSIDMKD SDGDSSKPSS
     KATSVQNSPA IQKGDDDERK AATKPLLRKE KSPQMLNVAD QRLLDASQLF KRKQGKGTVD
     VWWLFDDGGL TLLIPYLLTN KKKWNDCKIR VFIGGKINRI DHDRRAMATL LSKFRIDFSD
     INVLGDINTK PKKENVTAFE EMIEPYRLKE DDMEQDTAEA LKASEPWRIT DNELELYRAK
     TNRQIRLNEL LKEHSSTANL IVMSMPLARK GAVSSALYMS WLETLSKDLP PLLLVRGNHQ
     SVLTFYS
//
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