ID A9QPJ7_METI4 Unreviewed; 648 AA.
AC A9QPJ7;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Succinate dehydrogenase flavoprotein subunit {ECO:0000313|EMBL:ABX56655.1};
DE SubName: Full=Succinate dehydrogenase/fumarate reductase, flavoprotein subunit {ECO:0000313|EMBL:ACD82446.1};
GN Name=sdhA {ECO:0000313|EMBL:ABX56655.1};
GN OrderedLocusNames=Minf_0388 {ECO:0000313|EMBL:ACD82446.1};
OS Methylacidiphilum infernorum (isolate V4) (Methylokorus infernorum (strain
OS V4)).
OC Bacteria; Verrucomicrobiota; Methylacidiphilae; Methylacidiphilales;
OC Methylacidiphilaceae; Methylacidiphilum (ex Ratnadevi et al. 2023).
OX NCBI_TaxID=481448 {ECO:0000313|EMBL:ABX56655.1};
RN [1] {ECO:0000313|EMBL:ABX56655.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=V4 {ECO:0000313|EMBL:ABX56655.1};
RX PubMed=18004300; DOI=10.1038/nature06411;
RA Dunfield P.F., Yuryev A., Senin P., Smirnova A.V., Stott M.B., Hou S.,
RA Ly B., Saw J.H., Zhou Z., Ren Y., Wang J., Mountain B.W., Crowe M.A.,
RA Weatherby T.M., Bodelier P.L.E., Liesack W., Feng L., Wang L., Alam M.;
RT "Methane oxidation by an extremely acidophilic bacterium of the phylum
RT Verrucomicrobia.";
RL Nature 450:879-882(2007).
RN [2] {ECO:0000313|EMBL:ACD82446.1, ECO:0000313|Proteomes:UP000009149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate V4 {ECO:0000313|Proteomes:UP000009149}, and V4
RC {ECO:0000313|EMBL:ACD82446.1};
RX PubMed=18593465; DOI=10.1186/1745-6150-3-26;
RA Hou S., Makarova K.S., Saw J.H., Senin P., Ly B.V., Zhou Z., Ren Y.,
RA Wang J., Galperin M.Y., Omelchenko M.V., Wolf Y.I., Yutin N., Koonin E.V.,
RA Stott M.B., Mountain B.W., Crowe M.A., Smirnova A.V., Dunfield P.F.,
RA Feng L., Wang L., Alam M.;
RT "Complete genome sequence of the extremely acidophilic methanotroph isolate
RT V4, Methylacidiphilum infernorum, a representative of the bacterial phylum
RT Verrucomicrobia.";
RL Biol. Direct 3:26-26(2008).
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DR EMBL; EU223913; ABX56655.1; -; Genomic_DNA.
DR EMBL; CP000975; ACD82446.1; -; Genomic_DNA.
DR RefSeq; WP_012462728.1; NC_010794.1.
DR AlphaFoldDB; A9QPJ7; -.
DR STRING; 481448.Minf_0388; -.
DR KEGG; min:Minf_0388; -.
DR eggNOG; COG1053; Bacteria.
DR HOGENOM; CLU_014312_7_0_0; -.
DR OrthoDB; 9806724at2; -.
DR Proteomes; UP000009149; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.20.58.100; Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain; 1.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR InterPro; IPR030664; SdhA/FrdA/AprA.
DR InterPro; IPR011280; Succ_DH/Fum_Rdt_flav_su.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR NCBIfam; TIGR01811; sdhA_Bsu; 1.
DR PANTHER; PTHR11632; SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT; 1.
DR PANTHER; PTHR11632:SF53; SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF02910; Succ_DH_flav_C; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF46977; Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 47..452
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
FT DOMAIN 513..647
FT /note="Fumarate reductase/succinate dehydrogenase
FT flavoprotein-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02910"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 341
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR630664-50"
SQ SEQUENCE 648 AA; 71830 MW; 7FB608A1A9DBA01B CRC64;
MSIKPDHDER ISLPDARIPS GPLSGKWQKH KNTVALVSPG NRQKYKVIVV GTGLAGAAAA
ATLGELGYQV ESFCIQDSPR RAHSVAAQGG INAAKNYRND CDSVYRLFYE TIKGGDFRAR
EANVYRLAEI STSIIDHCVA LGVPFAREYG GMLANRSFGG VQVSRTFYAR GATGQQLLLA
AYSALNRQLA LGTVSIHPRT EILDIVIIEG HAKGVIARDL ASGEISSYSA DAVVLATGGY
GNIYYLSTNG RGSNATAIWR AYKRGAAFAN PCFTQIHPTC IPVSGDYQSK LTLMSESLRN
DGRIWVPSKK GEQRSPSGIP EVDRDYFLER LYPAYGNLVP RDIASRAIKR ICDEGYGVGP
GGLGVYLDFS DTIRKKGIDY LRERYGNLFD IYKEITGENA YITPMRIYPA VHYVMGGLWV
DYHLMSTIPG LFVIGEANFS DHGANRLGAS ALMQGLADGF FILPNTICDY LAKVGPWKIS
PDRTEFKSLE KEVMKRCKNL LERKGKKTAS HFHKQLGQIL WDKCGMVRNG PGLREALAQI
LELKEQFDKE IIVGGAEEGI NQSLEYALRV ADYFELAELM CRDALAREES CGCHFREEYQ
TPDGEGIRND KDYAHVALWF YRGKTNNPLL VKEPLVYEEI HFAARSYK
//
