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Database: UniProt
Entry: A9RTC0_PHYPA
LinkDB: A9RTC0_PHYPA
Original site: A9RTC0_PHYPA 
ID   A9RTC0_PHYPA            Unreviewed;       113 AA.
AC   A9RTC0;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   05-JUN-2019, entry version 54.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 9 {ECO:0000256|RuleBase:RU364145};
DE   AltName: Full=Mediator complex subunit 9 {ECO:0000256|RuleBase:RU364145};
GN   Name=MED9 {ECO:0000256|RuleBase:RU364145};
GN   ORFNames=PHYPA_025738 {ECO:0000313|EMBL:PNR31617.1}, PHYPADRAFT_160865
GN   {ECO:0000313|EMBL:EDQ77891.1};
OS   Physcomitrella patens subsp. patens (Moss).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC   Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae;
OC   Physcomitrella.
OX   NCBI_TaxID=3218;
RN   [1] {ECO:0000313|EMBL:EDQ77891.1, ECO:0000313|Proteomes:UP000006727}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Gransden 2004 {ECO:0000313|Proteomes:UP000006727};
RX   PubMed=18079367; DOI=10.1126/science.1150646;
RA   Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA   Nishiyama T., Perroud P.F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA   Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA   Suzuki Y., Hashimoto S., Yamaguchi K., Sugano S., Kohara Y.,
RA   Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B.,
RA   Barker E., Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K.,
RA   Estelle M., Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A.,
RA   Hughes J., Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R.,
RA   Pils B., Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J.,
RA   Sanderfoot A., Schween G., Shiu S.H., Stueber K., Theodoulou F.L.,
RA   Tu H., Van de Peer Y., Verrier P.J., Waters E., Wood A., Yang L.,
RA   Cove D., Cuming A.C., Hasebe M., Lucas S., Mishler B.D., Reski R.,
RA   Grigoriev I.V., Quatrano R.S., Boore J.L.;
RT   "The Physcomitrella genome reveals evolutionary insights into the
RT   conquest of land by plants.";
RL   Science 319:64-69(2008).
RN   [2] {ECO:0000313|EMBL:PNR31617.1, ECO:0000313|Proteomes:UP000006727}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Gransden 2004 {ECO:0000313|Proteomes:UP000006727};
RX   PubMed=29237241; DOI=10.1111/tpj.13801;
RA   Lang D., Ullrich K.K., Murat F., Fuchs J., Jenkins J., Haas F.B.,
RA   Piednoel M., Gundlach H., Van Bel M., Meyberg R., Vives C., Morata J.,
RA   Symeonidi A., Hiss M., Muchero W., Kamisugi Y., Saleh O., Blanc G.,
RA   Decker E.L., van Gessel N., Grimwood J., Hayes R.D., Graham S.W.,
RA   Gunter L.E., McDaniel S.F., Hoernstein S.N.W., Larsson A., Li F.W.,
RA   Perroud P.F., Phillips J., Ranjan P., Rokshar D.S., Rothfels C.J.,
RA   Schneider L., Shu S., Stevenson D.W., Thummler F., Tillich M.,
RA   Villarreal Aguilar J.C., Widiez T., Wong G.K., Wymore A., Zhang Y.,
RA   Zimmer A.D., Quatrano R.S., Mayer K.F.X., Goodstein D.,
RA   Casacuberta J.M., Vandepoele K., Reski R., Cuming A.C., Tuskan G.A.,
RA   Maumus F., Salse J., Schmutz J., Rensing S.A.;
RT   "The Physcomitrella patens chromosome-scale assembly reveals moss
RT   genome structure and evolution.";
RL   Plant J. 93:515-533(2018).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator
CC       involved in the regulated transcription of nearly all RNA
CC       polymerase II-dependent genes. Mediator functions as a bridge to
CC       convey information from gene-specific regulatory proteins to the
CC       basal RNA polymerase II transcription machinery. Mediator is
CC       recruited to promoters by direct interactions with regulatory
CC       proteins and serves as a scaffold for the assembly of a functional
CC       preinitiation complex with RNA polymerase II and the general
CC       transcription factors. {ECO:0000256|RuleBase:RU364145}.
CC   -!- SUBUNIT: Component of the Mediator complex.
CC       {ECO:0000256|RuleBase:RU364145}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364145}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 9 family.
CC       {ECO:0000256|RuleBase:RU364145}.
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DR   EMBL; DS544916; EDQ77891.1; -; Genomic_DNA.
DR   EMBL; ABEU02000021; PNR31617.1; -; Genomic_DNA.
DR   RefSeq; XP_001757406.1; XM_001757354.1.
DR   eggNOG; ENOG410J0KT; Eukaryota.
DR   eggNOG; ENOG410XZ8D; LUCA.
DR   InParanoid; A9RTC0; -.
DR   OMA; SMVERIY; -.
DR   Proteomes; UP000006727; Chromosome 21.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR011425; Med9.
DR   InterPro; IPR038790; Med9_plant.
DR   PANTHER; PTHR37188; PTHR37188; 1.
DR   Pfam; PF07544; Med9; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU364145};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006727};
KW   Nucleus {ECO:0000256|RuleBase:RU364145};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006727};
KW   Transcription {ECO:0000256|RuleBase:RU364145};
KW   Transcription regulation {ECO:0000256|RuleBase:RU364145}.
FT   COILED       51     71       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   113 AA;  13123 MW;  67AE7E809233FE90 CRC64;
     MSWSQAQSQA QSEWQQQPYQ TQAFHFSLVP VIDALAGAVE RGSRDQHDEL IRELVARFQK
     AEQILHSLES NSIEKDVATQ KRTLDDHRNK LEERRAVLAK YKSMVERIYP ADN
//
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