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Database: UniProt
Entry: A9ST59_PHYPA
LinkDB: A9ST59_PHYPA
Original site: A9ST59_PHYPA 
ID   A9ST59_PHYPA            Unreviewed;       802 AA.
AC   A9ST59;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   23-MAY-2018, entry version 41.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=PHYPADRAFT_134945 {ECO:0000313|EMBL:EDQ65666.1};
OS   Physcomitrella patens subsp. patens (Moss).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC   Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae;
OC   Physcomitrella.
OX   NCBI_TaxID=3218;
RN   [1] {ECO:0000313|EMBL:EDQ65666.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=18079367; DOI=10.1126/science.1150646;
RA   Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA   Nishiyama T., Perroud P.F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA   Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA   Suzuki Y., Hashimoto S., Yamaguchi K., Sugano S., Kohara Y.,
RA   Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B.,
RA   Barker E., Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K.,
RA   Estelle M., Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A.,
RA   Hughes J., Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R.,
RA   Pils B., Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J.,
RA   Sanderfoot A., Schween G., Shiu S.H., Stueber K., Theodoulou F.L.,
RA   Tu H., Van de Peer Y., Verrier P.J., Waters E., Wood A., Yang L.,
RA   Cove D., Cuming A.C., Hasebe M., Lucas S., Mishler B.D., Reski R.,
RA   Grigoriev I.V., Quatrano R.S., Boore J.L.;
RT   "The Physcomitrella genome reveals evolutionary insights into the
RT   conquest of land by plants.";
RL   Science 319:64-69(2008).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; DS545004; EDQ65666.1; -; Genomic_DNA.
DR   RefSeq; XP_001769505.1; XM_001769453.1.
DR   KEGG; ppp:PHYPADRAFT_134945; -.
DR   InParanoid; A9ST59; -.
DR   KO; K02154; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000325; C:plant-type vacuole; IBA:GO_Central.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    411    435       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    456    473       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    536    554       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    566    589       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    625    643       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    746    770       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       81    117       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   802 AA;  92067 MW;  3E0C570716FCB884 CRC64;
     MDLFRSEEMN KVQLIIPVEA AHNTVTYLAE LGLIQLIDLN SGKSPFQRPF ASQTKRCEEM
     ARKLRWFQDQ LLRAKQTPVC RHTLERELKL EELEMKLTEL ETELLESNCN SEKLKRSYSE
     LMEMGLVLHK TSTSFNSARR TADIQRRQPD LIVDAEDVNH PFLLEQEASI NPSKQAQLGF
     VAGLVVNSKC HSFERILFHA TRGNMYFKRS TQADFVADPA SGEQVEKVVF IVFFAGERAR
     LKITKICETF GVNRYPFPED SARQGLMKVE VSTRLSELQA TLNSGVVHRQ NVFTNLGYNL
     DHWIGMVRRE KAVYCALNML SVDVTSKCLV AEGWCPVKTK PQIQDALQRA TVDSNSQLSS
     IFHVVQTKES PPTFYETNKF TAPFQEIVNA YGVARYQEAN PGCFTIVTFP FLFAVMFGDW
     GHGIALLSAA LYLILKENHF ESKKLGDFMT MAFGGRYIIL LMSIFSIYTG FIYNEFFSVP
     IFIWDSAYSC RENDCSDASR IGLVKWSELP YPFGLDPAWH GSRTELPFTN SLKMKMSVLM
     GVSQLNLGLM LSWWNADFNH SKLDFWYQFV PQLLFLNSLF GYLSMLIVIK WCQGSKADLY
     HVMIYMFLSP SEPLGENQLF WGQNYFQRML VMIALAAVPW MLFPKPFKLR KLHEQRMQGR
     IYGVLGGSDT ESVDLEHEEE FNFNEIFVHQ MIHTIEFVLG TVSNTASYLR LWALSLAHAQ
     LSSVFFEKFL VLSFSYSNPF VRLTGLVMFA FVTVGVLLLM ESLSALLHAL RLHWVEFQNK
     FYAGDGYKFM PFSFKDLESD NI
//
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