ID A9UQK5_MONBE Unreviewed; 1447 AA.
AC A9UQK5;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Purple acid phosphatase {ECO:0000256|RuleBase:RU361203};
DE EC=3.1.3.2 {ECO:0000256|RuleBase:RU361203};
GN ORFNames=MONBRDRAFT_30984 {ECO:0000313|EMBL:EDQ92614.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ92614.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ92614.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC Evidence={ECO:0000256|RuleBase:RU361203};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. GB1/RHD3 GTPase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01052}.
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily. Purple
CC acid phosphatase family. {ECO:0000256|RuleBase:RU361203}.
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DR EMBL; CH991543; EDQ92614.1; -; Genomic_DNA.
DR RefSeq; XP_001742376.1; XM_001742324.1.
DR EnsemblProtists; EDQ92614; EDQ92614; MONBRDRAFT_30984.
DR GeneID; 5887615; -.
DR KEGG; mbr:MONBRDRAFT_30984; -.
DR eggNOG; KOG1378; Eukaryota.
DR eggNOG; KOG2037; Eukaryota.
DR InParanoid; A9UQK5; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003993; F:acid phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd00839; MPP_PAPs; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.60.40.380; Purple acid phosphatase-like, N-terminal; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR040974; Fn3_PAP.
DR InterPro; IPR030386; G_GB1_RHD3_dom.
DR InterPro; IPR015894; Guanylate-bd_N.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041792; MPP_PAP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008963; Purple_acid_Pase-like_N.
DR InterPro; IPR015914; Purple_acid_Pase_N.
DR InterPro; IPR025733; Purple_acid_PPase_C_dom.
DR PANTHER; PTHR45778:SF3; PURPLE ACID PHOSPHATASE; 1.
DR PANTHER; PTHR45778; PURPLE ACID PHOSPHATASE-RELATED; 1.
DR Pfam; PF17808; fn3_PAP; 1.
DR Pfam; PF02263; GBP; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF14008; Metallophos_C; 1.
DR Pfam; PF16656; Pur_ac_phosph_N; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49363; Purple acid phosphatase, N-terminal domain; 1.
DR PROSITE; PS51715; G_GB1_RHD3; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|RuleBase:RU361203};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU361203};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|RuleBase:RU361203"
FT CHAIN 18..1447
FT /note="Purple acid phosphatase"
FT /evidence="ECO:0000256|RuleBase:RU361203"
FT /id="PRO_5005122269"
FT TRANSMEM 787..809
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 875..894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 75..231
FT /note="GB1/RHD3-type G"
FT /evidence="ECO:0000259|PROSITE:PS51715"
FT REGION 831..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1222..1241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1447 AA; 160811 MW; E13F8121F12589C5 CRC64;
MGWQYWIMGL VLAGVCGNHH GWPGAVANAS LLTLQEKLLP AHQSAARPLQ LVGRDQTGRL
AVNRSSLQYI ATNWHEPVYV VGVVGPFHSG KSFLANRLVD RMAGFTLGPT VQPTTEGIWT
FSVPATDGQR LRVVVLDTEG LAAPGNSPDY DAALFAVTTL LSTHLVYNSV RIIDEAAMEY
LEVLARRAQL FQFQTALRSQ SQFSPAMLNF PSLTWVVQDF FQEQIDGESP DAWLRRLMDQ
QAALAPADLT ADYIKDIEAV QQHLVELLRQ KHTETPHEAS ATLSDEAPSG LSQLSRALLS
IAAPRQHSAP SQALTPAQFV FLVDLLVTTV NNGGLGQLPS QWSMLVREQA VQAREQSLQA
SGLADVLARA FFRRMVEDLL AVQPPLAELL FEQQLHDAKA ATIKGFERQM FDLDTRFAQD
AIGTLKAELK LLTKQTTERY LAKTQAHVER ILREAEDKFV ASLGGLRQMM TEELDSYLQS
SMDALQRQTA GQFAPYGSNG RAADVKRMTS RLLVGKAAGK LLAVMQQRCE VAQARNLRRI
VASMQQATFA ALIHAKKAIA EVGMVMWSQE ELQVKQDAVL AEALAVFGRQ TDGYHQHPAH
DQEKTNLLAQ LQTLAYQWRD DNEALVRRHI KSLEAEIQQE VHEVLVQVQL PISIQEENKL
VAEQTRRAYR KFRKVALRFE GMPSYNQGLV ALQTRLDELA KAFGEDNVRQ LRERVEKPLQ
RARRRLRALV ADYGLVLNLH GYARTYAREE IGQRLEADHC QRVIQAWMTG SGPENVGDML
RENDQGLLNL SLVVGIAGIF LFLLIRVLCR SSVAARPVRI KADVASKHPL VKEDWSEKER
EKEREREKSE REKERAREER REREETKQRE ESQRMTAMSV LAVVAIALVA AVAARPARVA
TLDLSSQVQL SLNATTISDG DWVQLSWSGV PEAERASCWI GVFSPDNVDV STIPAIPYPA
TAPWTATAAL KYQVCSADPS FASTGAGSYN FRLLDMRETV AFWLFYNGTT NPVAVNKSDV
ISFTHPEAPR HGVLALTADP TEMRLTWNSK FPTPGFVNYT VNGAATAVSI PAKAYTYTTD
DLCGEPGRTQ GWREPGFFHT AVIKGLTPGT DKVSYIYGND QYGWSETKTF TAAKSADPNA
ALRVLVAADV GATEPDHCSY HWIEPNATQT YQHMTDLASS ADVVLHIGDI SYATGYSAKW
ELFMAQAEPL GSVLPIMTAL GNHEQDTPDR RSGTYYGSND SGGECAQPTN ARFPMPVPSH
NQFSGWYSFD MGPVHFITIN TELEVAPGSD QYDFITDDIA QMNRSETPWL IMMGHRPMYY
VRDDVSAIDP HFQVLESLMY ENKVDLFLVG HVHNALVTCP VYNGTCAKSM DEDLFQGTVH
VCVGNGGMSL DKVPKTAPAW GDFMASDWGY ATLDVANKTH LTMSLFEDST NVELYSFSLK
RNYPRAL
//
