ID   A9US87_MONBE            Unreviewed;       904 AA.
AC   A9US87;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   24-JAN-2024, entry version 69.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|Pfam:PF03810};
GN   ORFNames=MONBRDRAFT_17564 {ECO:0000313|EMBL:EDQ91738.1};
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ91738.1, ECO:0000313|Proteomes:UP000001357};
RN   [1] {ECO:0000313|EMBL:EDQ91738.1, ECO:0000313|Proteomes:UP000001357}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC       subfamily. {ECO:0000256|ARBA:ARBA00038423}.
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DR   EMBL; CH991544; EDQ91738.1; -; Genomic_DNA.
DR   RefSeq; XP_001743024.1; XM_001742972.1.
DR   AlphaFoldDB; A9US87; -.
DR   STRING; 81824.A9US87; -.
DR   EnsemblProtists; EDQ91738; EDQ91738; MONBRDRAFT_17564.
DR   GeneID; 5888548; -.
DR   KEGG; mbr:MONBRDRAFT_17564; -.
DR   eggNOG; KOG2023; Eukaryota.
DR   InParanoid; A9US87; -.
DR   OMA; AQEGAMS; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR   GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527:SF3; FI21453P1-RELATED; 1.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001357}.
FT   DOMAIN          35..100
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03810"
FT   REGION          324..390
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..368
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        369..390
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   904 AA;  101366 MW;  FA97741BEBC9A9DC CRC64;
     MADQGFVPDQ GFVQQVLQVL VQCQSTNSQE MAASQEMLKQ LNERPEVNIY LCHILVNEVS
     VGPNTRSMAA ILLKNNVRWN IDKLSFPIVQ YLKNEAVRAL ADPSQLVRKV AATLVSTLVV
     RLGLKHWPEA IPTLLHLMQN SDPNGLEGTL TALTFICEDD APWLCEYEAG RLVDLIMKTV
     VLLFRHEDPS IRSKALQCSN VFVSFETPGF NANFQSYLQG VFALAPDTNP VVRMHVCTAM
     VSIVESKFEQ AVPFLEPELG NITQYMLDCT RSEDEGVALE ACEFWMVMAD KPFSSQVLDP
     IMPQLLPLLL DRMQWSEFEL ATMSADDDAD EEDRDEDVRP ATHKAAVHGE RRTRRDDGDG
     QEGAVGHDGE GGDEDEDDED DDDDYDDEDG ADEWSIRKCA AMTLDSFAVK YHTGLLPVLM
     PLLKQMFESN VWLAQEACML ALGAIADGCK DEMETYLPEI LPFIAGFFEH EQHLVRSITC
     WCFRRYAEYI CKTPAMLEAT LGALTARLVD RNKKVQETAC TALCHIQEIA SNRLEPFTEN
     LLRTYCYALD HFKRRNRLHL YDCISTMADA VGGALAEARY VNELVPRLLN QWQAMDDHCL
     DAFHITECLS VILGAVETEY LPYAEMTYAM AVNVLRVNIA RSVAHQEGQD TEDPDDDMIV
     GALDLISSMV ESLQGDMEPF ISADLMELLL YGLQDELAEM RQSAFAVLGD LSKALFGVVL
     PHLDTVMLFI SVNLTMEEPP VCNNAIWATG EIALHLGENM NKYVDDLLEP IIHILNTSEL
     NTLTENAAIT IGRLGLGCTL KVAQHLPNLL ERWCRALRLV DDNDEKDSSF EGICLAVLAN
     AHGALPRFML LCDAISKFQQ PSPKLAELFA RLLAHFKTAA GGEWERFFAH FPELRQELMV
     KYNV
//