ID A9USN6_MONBE Unreviewed; 954 AA.
AC A9USN6;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=non-specific protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011903};
DE EC=2.7.10.2 {ECO:0000256|ARBA:ARBA00011903};
GN ORFNames=MONBRDRAFT_44336 {ECO:0000313|EMBL:EDQ92133.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ92133.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ92133.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001149};
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DR EMBL; CH991544; EDQ92133.1; -; Genomic_DNA.
DR RefSeq; XP_001743419.1; XM_001743367.1.
DR AlphaFoldDB; A9USN6; -.
DR STRING; 81824.A9USN6; -.
DR EnsemblProtists; EDQ92133; EDQ92133; MONBRDRAFT_44336.
DR GeneID; 5888420; -.
DR KEGG; mbr:MONBRDRAFT_44336; -.
DR eggNOG; KOG0197; Eukaryota.
DR eggNOG; KOG1026; Eukaryota.
DR InParanoid; A9USN6; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00192; PTKc; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF600; PDGF-AND VEGF-RECEPTOR RELATED, ISOFORM J; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00233; PH; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00219; TyrKc; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 2.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT DOMAIN 10..101
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 208..482
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 532..818
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 844..950
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 147..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 247
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 954 AA; 105569 MW; 13766F02A3ED0BDA CRC64;
MDDDERLQIW LSRHISRQDA ETALKGHPDG TYLIRASVSA PGDYVLCVVC HGQIQHHQVC
IKHNNGRMLT RSGRELQNLS ELLRHYKTTL DGLEVLLREG TSYFDPPSSA PKGYVNLVHQ
ATVDHDYENT KDLSPTLINK MKAAAVRDST RRPAPVPQDG AGPNEDVLPT PKGYVNLKKG
ETGADVVPTP AGDGIPDLVE FEIPQERLQI MSELGSGHYG QVFEAWLMPD PDDFKAQRKK
GKLVAVKSLK AHGNDGAVRA FLGEARTLSQ FSHPNVLGLL GVVTRSKPWH MITEHIPYGD
VRSVLKACRS ASTAVHAHEQ VYMAAQAAAG MEYLASLGFV HRDLAARNIL LGRYCHIKLA
DFGLSRALDT ESQYYVVQSR SLLPFRWMSI EALKEGKFTT QSDVWAFGVL LWEIMSMAKT
PWRKNSTQEV KQLILAGERL PPPRNCPQTL YSLMTTCWQP APAARPTFVT LRRSLEQQGE
LLNPEKLKPR DIGQFAPRST SGPSAAMLKF DPEEQSRASN LIEDLQMPRD ELIVINELGA
GDFYQLVLME MTSGLTGGAK CHVAAKMLKD NATEADREAF DAEVNLRASE LLDHPNVVAL
IGLCTKDEPP FMVMEYLSLG DLQSYLTASA PAPGQVCPAR ARRSIPRSFH PLSLSTYEQT
SMARDIAAGM SYLAERDIVH RDLAARNCVV GQGPVVKISN FGLGKTLRGG DYYSSSSGVM
PVRWMAPEAV CFGKHSCASD VWSFGIVLAE IFTFGEKPFA HMTDLEICNA YASGGMSALP
VPPSAPDVIV HCMQECLKGE PKERVSFEQL QEMLDEELSE ENVDVDEEPM PLVDDIDWVS
GIGEFVHTGW MIKQGSGQGA FSRSSWKRRW FALRDNGTLS YHKAERPDAK PLGTIALGDT
IKVHPRPPFE LTFAQKSCFS MVTPGRVYNF VCDSDGERDV WIRLLKAAID ALHS
//
