ID A9UTM7_MONBE Unreviewed; 578 AA.
AC A9UTM7;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=Saposin B-type domain-containing protein {ECO:0000259|PROSITE:PS50015};
GN ORFNames=MONBRDRAFT_34989 {ECO:0000313|EMBL:EDQ91273.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ91273.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ91273.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
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DR EMBL; CH991545; EDQ91273.1; -; Genomic_DNA.
DR RefSeq; XP_001743695.1; XM_001743643.1.
DR AlphaFoldDB; A9UTM7; -.
DR EnsemblProtists; EDQ91273; EDQ91273; MONBRDRAFT_34989.
DR GeneID; 5888929; -.
DR KEGG; mbr:MONBRDRAFT_34989; -.
DR eggNOG; ENOG502QVQW; Eukaryota.
DR InParanoid; A9UTM7; -.
DR OMA; PFCHLYP; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0050528; F:acyloxyacyl hydrolase activity; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0009104; P:lipopolysaccharide catabolic process; IBA:GO_Central.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IBA:GO_Central.
DR Gene3D; 1.10.225.10; Saposin-like; 1.
DR InterPro; IPR039676; AOAH.
DR InterPro; IPR048593; AOAH_Saposin_N.
DR InterPro; IPR001087; GDSL.
DR InterPro; IPR011001; Saposin-like.
DR InterPro; IPR008139; SaposinB_dom.
DR PANTHER; PTHR15010; ACYLOXYACYL HYDROLASE; 1.
DR PANTHER; PTHR15010:SF0; ACYLOXYACYL HYDROLASE; 1.
DR Pfam; PF00657; Lipase_GDSL; 1.
DR Pfam; PF20825; Saposin; 1.
DR SMART; SM00741; SapB; 1.
DR SUPFAM; SSF47862; Saposin; 1.
DR SUPFAM; SSF52266; SGNH hydrolase; 1.
DR PROSITE; PS50015; SAP_B; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..578
FT /note="Saposin B-type domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002744900"
FT DOMAIN 42..121
FT /note="Saposin B-type"
FT /evidence="ECO:0000259|PROSITE:PS50015"
SQ SEQUENCE 578 AA; 63146 MW; D8D8E6771F679F97 CRC64;
MAPRLLLTGV ALLALCASGT QAFFWSFDGT STKTNLQGGV NGGTGCAVCT LGVGIVEQLT
EIHNESAIEA VERLCQMLPS NETAKCQELV KVLGPTVIDL IEQKYTADVV CKAIGVCTGD
CRLFPAPAEG MAQSVARARA SLPFGRLAAV QDLPAICDLP LLKDVCDIIY NWANNHEPLD
DLDQDGFSPL HTLRGADWRG KDCDDTNKDV RPGRRPIDSD ANLDSNCNGI FGIDPTTNKA
YEDLFCADTP HYGIAVLGDS ASAHFHLQPQ YLNTTAYSNT TFDRLLFSIE NEFDWPMMSA
STAFAGPNDF APDISGPDNS TYMVARNRNR CIHRDFQNIA VNGARAGSMN STIVKTLARN
QQEDYPLFVV YALIGNDVCN GHEDTLSHMT TPADMYAQAM GALEQLEHTL PNGSHVFFMG
LADGSILYDT MANRTHPIGA LHNDVKTKDV YAFLNCLQIS PCRGWMNSNE TLRALTTDHA
NLLSSVLENI TKTQTFSNFD LHYFPNPLTE AIKEFVAAGG QAWQLIEPVD GFHPSQLAQP
LITDQLWKFL SANFSDIMQP INPHNADIDK VFGDQGGH
//
