ID A9UTY2_MONBE Unreviewed; 333 AA.
AC A9UTY2;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN ORFNames=MONBRDRAFT_6461 {ECO:0000313|EMBL:EDQ91573.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ91573.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ91573.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CH991545; EDQ91573.1; -; Genomic_DNA.
DR RefSeq; XP_001743995.1; XM_001743943.1.
DR AlphaFoldDB; A9UTY2; -.
DR STRING; 81824.A9UTY2; -.
DR EnsemblProtists; EDQ91573; EDQ91573; MONBRDRAFT_6461.
DR GeneID; 5889007; -.
DR KEGG; mbr:MONBRDRAFT_6461; -.
DR eggNOG; KOG2059; Eukaryota.
DR InParanoid; A9UTY2; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01238; PH_Btk; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR14336:SF8; DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE; 1.
DR PANTHER; PTHR14336; TANDEM PH DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 102..208
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 254..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 333 AA; 37653 MW; 60A5BA8B1EA4B82B CRC64;
MRHGVASRQE AHLGKKEVND FELAKVASLH QGRAAVFISI IDIGGCDELF ENNHNALLGR
TVHNGTGLAL LRFGTMGSQR MCQPDSASTI ITMKENLEVD PEPVLVGTLL KRAQGKSTFG
RMNWKQRWFV LYENELQWWS AEGGRYNTQA ELKGAIDLAS IHAVEHVSYD AFTKAHMFQL
VHTSLLYIQC NTKRECDKWV STLRKLVAHN TFLHPKFHPG FFDERDKVWS CCGIPSRDFK
GCLTAHDYSP IRKELDADET RPQAKRGISS SAAVEEAHAA DARAREEERK HQQRHAVNHQ
EHRLKSVDSC GATNVEQVDP RPPHKRSSQD ALR
//
