ID   A9UU62_MONBE            Unreviewed;       809 AA.
AC   A9UU62;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   RecName: Full=Methyltransferase type 12 domain-containing protein {ECO:0000259|Pfam:PF08242};
GN   ORFNames=MONBRDRAFT_36263 {ECO:0000313|EMBL:EDQ91612.1};
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ91612.1, ECO:0000313|Proteomes:UP000001357};
RN   [1] {ECO:0000313|EMBL:EDQ91612.1, ECO:0000313|Proteomes:UP000001357}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
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DR   EMBL; CH991545; EDQ91612.1; -; Genomic_DNA.
DR   RefSeq; XP_001744034.1; XM_001743982.1.
DR   AlphaFoldDB; A9UU62; -.
DR   STRING; 81824.A9UU62; -.
DR   EnsemblProtists; EDQ91612; EDQ91612; MONBRDRAFT_36263.
DR   GeneID; 5889150; -.
DR   KEGG; mbr:MONBRDRAFT_36263; -.
DR   eggNOG; ENOG502QQCH; Eukaryota.
DR   InParanoid; A9UU62; -.
DR   OMA; YGYIVGE; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR021829; DUF3419.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR47473; BTA1P; 1.
DR   PANTHER; PTHR47473:SF1; METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF11899; DUF3419; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        57..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        220..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          561..668
FT                   /note="Methyltransferase type 12"
FT                   /evidence="ECO:0000259|Pfam:PF08242"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          770..809
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   809 AA;  90701 MW;  533439B81C9C0820 CRC64;
     MANSDMDMTK LGNGPRARRT SRGLERSRAH LRQHRSRTGS EEEKQNINTL SWVKFSLLLA
     FDVTMIGINT CIWTLASVFL FCFSKCHDWL LMKLVGVNYL YNVSWEDPRV DRTALKLHEG
     DHVLTIASAG DNVLDFIIDG AKVTAVDLNA CQLALCSLKR AAILELNHDE FFRIFAKQDM
     DLLRNKYHLL KKHMDANAIK FWDSKLPSFS GFMYSGSSGW LAFFLFRVLF PVTGFSWIRA
     ALVEGVSQDD FRRRVKNHEA RLEWLAWIAD SVLMPIFAPL AGVPEAQLNL GMSREGNVHT
     IMERVFLNTD LVEDNYFFYG YIVGEYSERC CPRYLKAEHF STLKRAMAGG KLILYHGTLA
     DRLRLDAQVA KPPSYTAAIM LDHLDWMDDM MVNEELSLLW PLLNNDTGRV LWRSFSDEPH
     RAALKHLSAE KVDNGSGDRT GMYWGVWVAG KNTCGNHPEL TSPGLFWQEQ QPMSLVDKVV
     TGAKIVTFPV LSPVLSMASN AAARLTGVSK EDLTNNAHAK KIEAFYASQA DAYDAFRENF
     LHARVHLATC LPLPPGELTW VDVGAGTARN LEFFPVDTLK RRFKKIYILD ISASLLDVAR
     RRVEAAGLSD VVELVLADFT DLSDKGKSAL PAPGSVDLVT FSYSLSMIPD KRSALQQATR
     LLAPGGSLGI ADFFYRNDSD TYKDKPVSKW ISHVYDLGCK LWFRQDGVHL LSNDVLDTLN
     DSTELTCAER FRGSVPLLPI LNPWHGIHIT RKLSAKDREV FTDSAASSVA SIVEEEEEEN
     SLDAESKPKP MNGHATGKGK GKGKKNKSK
//