ID A9UWV5_MONBE Unreviewed; 705 AA.
AC A9UWV5;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Alpha-type protein kinase domain-containing protein {ECO:0000259|PROSITE:PS51158};
GN ORFNames=MONBRDRAFT_24578 {ECO:0000313|EMBL:EDQ90281.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ90281.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ90281.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
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DR EMBL; CH991548; EDQ90281.1; -; Genomic_DNA.
DR RefSeq; XP_001745048.1; XM_001744996.1.
DR AlphaFoldDB; A9UWV5; -.
DR STRING; 81824.A9UWV5; -.
DR EnsemblProtists; EDQ90281; EDQ90281; MONBRDRAFT_24578.
DR GeneID; 5890316; -.
DR KEGG; mbr:MONBRDRAFT_24578; -.
DR eggNOG; ENOG502QVA3; Eukaryota.
DR InParanoid; A9UWV5; -.
DR OMA; RIEFLEC; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd17508; Alpha_kinase; 1.
DR Gene3D; 3.20.200.10; MHCK/EF2 kinase; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR004166; a-kinase_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR45992:SF13; ALPHA-TYPE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45992; EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED; 1.
DR Pfam; PF02816; Alpha_kinase; 1.
DR SMART; SM00811; Alpha_kinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51158; ALPHA_KINASE; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 666..696
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 406..658
FT /note="Alpha-type protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS51158"
SQ SEQUENCE 705 AA; 78361 MW; C680860ED68014D5 CRC64;
MSSLTNTVLL ELEEEEEEDV ITDLASNLNS VVISRRQGNL IRNPNNVSRA ALKEAIKLGR
RDKTRPGPSG ETRHKFIHRG MVYITDAAER QVISSWRIDG KDENPFDAPM ADPASRKIHA
VFVVDDSGSM RRDDVPGFSS RTEAVFKTLL KQFLQPQMEL TRQDPTASMN VSVSLILAAQ
EASVVLQRAP LDHSLEVGLE ELSSHTAMYH GFYLTGLAAL EKLLDEEKTS NSRIMVFWLS
DGAPSDHVHT PCTHGTRVWD SGYSNQLPEC PYGNAKYLCR PQVKRSVREK CLRQIRHLGD
TFGQHRLSFT TVGFGPAKED FHMLQDMAAV LPLGKFHKLG LNVHHLASVF TTLTSTMTTL
RTRLAGGGTT PNARKNKAAQ RIQNLDDSAV DSSVWDVYIG PDLVRKYTYS HAARAMMDVP
MEEGANGIAM RKEYFEAGAE RFAFECTEVA SRGAKHPAQA RGYALVAKES ATEEYLNIKF
YERAAKTQAF AQSMAERFNE RVRTTVGSLE TALRVSFAPC TIYEVKDPYY DNGIAWILAE
PSLEGKFVKW NSNSGEVKKH MHETVELPQG TTCDVDDVPQ AFSHFSYEVT GKEELICDLQ
GVWNAYDGFT LTDPAIHHIS ESKRHGKSRT DRGTEGIRQF METHTCSPLC RALGLSNCSV
CVCVCVCVCV CVCVCVCVCV CVCVCVCVCV CVCVCVRLRS QCISE
//