ID   A9UZE0_MONBE            Unreviewed;       637 AA.
AC   A9UZE0;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=TNFR-Cys domain-containing protein {ECO:0000259|PROSITE:PS50050};
GN   ORFNames=MONBRDRAFT_37065 {ECO:0000313|EMBL:EDQ89352.1};
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ89352.1, ECO:0000313|Proteomes:UP000001357};
RN   [1] {ECO:0000313|EMBL:EDQ89352.1, ECO:0000313|Proteomes:UP000001357}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR   EMBL; CH991551; EDQ89352.1; -; Genomic_DNA.
DR   RefSeq; XP_001745928.1; XM_001745876.1.
DR   AlphaFoldDB; A9UZE0; -.
DR   EnsemblProtists; EDQ89352; EDQ89352; MONBRDRAFT_37065.
DR   GeneID; 5891146; -.
DR   KEGG; mbr:MONBRDRAFT_37065; -.
DR   InParanoid; A9UZE0; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   Gene3D; 2.60.120.40; -; 1.
DR   Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR24019; ADIPOLIN; 1.
DR   PANTHER; PTHR24019:SF5; C1Q DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00020; TNFR_c6; 1.
DR   SMART; SM00208; TNFR; 2.
DR   SUPFAM; SSF49842; TNF-like; 1.
DR   PROSITE; PS50050; TNFR_NGFR_2; 2.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..637
FT                   /note="TNFR-Cys domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002744887"
FT   REPEAT          86..130
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   DOMAIN          86..130
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000259|PROSITE:PS50050"
FT   DOMAIN          135..178
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000259|PROSITE:PS50050"
FT   REPEAT          135..178
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   DISULFID        112..130
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ   SEQUENCE   637 AA;  68085 MW;  BC46F1E1D143A939 CRC64;
     MAGGSRRVLG LRLTLALVLG ALVPRAPGEE AVVVTDALGN LYINSSQEHG GQVFVNGVNV
     DELHALVNAM SQVVTTQARL IDALTPCADG TFLAQGETVS SARLCSPCTQ ACPENQWLAS
     PCTGLRNARC EPCTACDPNS EYEAHACTTH SDTVCLSCTD CLEDQALEPC SARADTICRP
     RNWGFSLDLE APLAWSSGNS VYHSLHGFEP AASGQRHATF IRAETSFNGS TATTAASLGY
     YLIAFNIRLE NLTNGWFQVG VHVNNGISFS SNGLSVAHGS AEIAARTFTS IGIVRLAPNT
     PFYVGVYAIN DPEFVVGLGS GLAAYRVQPT EGFYAMLTEE NFINVTGEAY PITGWSAASP
     NSATTFVFGG ELQDSVYTAK ESGVFLVTLS MMFDNRLRAS DDQDADPWAA DFDRLLVIVN
     EHATHKTPLQ AIRSWPYPHE FESVTFSALV FLQAGDQMRA GGYSHSTRSF SFLPHSHFSA
     ARLEPSLAFC ALKLSTSASS TSEAFEVTGW SDLTDSSGLC FDRGGAFNGT SGRFFALKAG
     FYYATATIRL DNLMNASHAT VSIRSSADSN ASSHEASGLS AVRTPFGGLN LRVESVSVAG
     LLYLDEGDYA SVWVHVQGTQ LAFEVNQESS FSMALID
//