ID A9UZW1_MONBE Unreviewed; 364 AA.
AC A9UZW1;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Endonuclease/exonuclease/phosphatase domain-containing protein {ECO:0000259|Pfam:PF03372};
GN ORFNames=MONBRDRAFT_37144 {ECO:0000313|EMBL:EDQ89303.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ89303.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ89303.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
CC -!- SIMILARITY: Belongs to the DNase I family.
CC {ECO:0000256|ARBA:ARBA00007359}.
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DR EMBL; CH991551; EDQ89303.1; -; Genomic_DNA.
DR RefSeq; XP_001745879.1; XM_001745827.1.
DR AlphaFoldDB; A9UZW1; -.
DR STRING; 81824.A9UZW1; -.
DR EnsemblProtists; EDQ89303; EDQ89303; MONBRDRAFT_37144.
DR GeneID; 5891221; -.
DR KEGG; mbr:MONBRDRAFT_37144; -.
DR eggNOG; ENOG502QQFT; Eukaryota.
DR InParanoid; A9UZW1; -.
DR OMA; DCSYVRE; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004530; F:deoxyribonuclease I activity; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0006308; P:DNA catabolic process; IBA:GO_Central.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR016202; DNase_I.
DR InterPro; IPR033125; DNASE_I_2.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR PANTHER; PTHR11371; DEOXYRIBONUCLEASE; 1.
DR PANTHER; PTHR11371:SF31; EXTRACELLULAR NUCLEASE; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR PRINTS; PR00130; DNASEI.
DR SMART; SM00476; DNaseIc; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR PROSITE; PS00918; DNASE_I_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357}.
FT DOMAIN 36..244
FT /note="Endonuclease/exonuclease/phosphatase"
FT /evidence="ECO:0000259|Pfam:PF03372"
FT REGION 152..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 364 AA; 38979 MW; DE41AF356D6DE7F3 CRC64;
MRWQGVCGKL GLTVVLVLTI GGPWLAAGRT TATLAAFNIQ VFGETKASKP DVMADIVSIC
HNFDFVAIQE IRDASSEALA TLMDALNENQ PTALQYINIT GPREGTTSSK EQYAFVYRPA
RIRVHDAFAL NMSETFERPP MAAIVEVLTP GSSNRSSTPA ALRGEAPLIT PGGPSSPRYP
VTSSLASSAG LFQVLVLHAK PSSDATYLEL SALDQARQIA TQYAGVEPTV LAGDFNAGCS
YLPADKEAEV TIFKSPYTVL INDSADTTST NSVCPYDRIV TFGNIGSRIL QSGIINTEAA
PFNFDQERAE AVSDHYPIAY EVAAATTTSD DNPAVDQPKI VHLAPQAKTD APRRQTARMV
PPLR
//
