ID A9V514_MONBE Unreviewed; 451 AA.
AC A9V514;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=TLC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=MONBRDRAFT_27351 {ECO:0000313|EMBL:EDQ87196.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ87196.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ87196.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the HRG family. {ECO:0000256|ARBA:ARBA00006203}.
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DR EMBL; CH991560; EDQ87196.1; -; Genomic_DNA.
DR RefSeq; XP_001747809.1; XM_001747757.1.
DR AlphaFoldDB; A9V514; -.
DR EnsemblProtists; EDQ87196; EDQ87196; MONBRDRAFT_27351.
DR GeneID; 5893223; -.
DR KEGG; mbr:MONBRDRAFT_27351; -.
DR InParanoid; A9V514; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015886; P:heme transport; IBA:GO_Central.
DR InterPro; IPR026218; HRG.
DR PANTHER; PTHR31525; HEME TRANSPORTER HRG1; 1.
DR PANTHER; PTHR31525:SF1; HEME TRANSPORTER HRG1; 1.
DR Pfam; PF16954; HRG; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 48..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 451 AA; 50007 MW; E5B98D3F96AE1A99 CRC64;
MAGPSDRVPL LAGHDYPSYF YRRLFAGFSV LVGVAGAAAF LLQFGHRWQV AVLALMQGAV
ALINYIEAHY RSKCFRDNKL PNNHAIGMRS VGAFATTVAL LVVLTYLTLA IQRKDQLTGE
SYWINAIWGF LLGKWGIVTF AFGEHISTYD AELYHLQQTD PLHVSVQENR EDFGTTHIYS
GLEDPPTNNR NERARVNVLS LSLSLSLSLS LSLSLSLSLS LSLSLSNSLS LSNSLSQTLS
QTLFLSLSLS FSLSLSLSLS LSLSFTFADN YFTIGQKQLS TVSLNGSSMP YFLSEIMTAP
DLDVLKWSAI TIWVGHFILD YVFHRIPATK AKSGIMAFEV IAGLSVAYLS WHGFIGEYFA
ADETVEDKVY GFLPRAQHMA EVMIMYQLYD LLVMFIYPSL FTMPMLIHHV LAGTLALLGS
FGYMHGSNCL PTLWFSCLSA INLHTSVDSI W
//
