ID A9V6U2_MONBE Unreviewed; 1319 AA.
AC A9V6U2;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=SH2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=MONBRDRAFT_10594 {ECO:0000313|EMBL:EDQ86866.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ86866.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ86866.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
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DR EMBL; CH991563; EDQ86866.1; -; Genomic_DNA.
DR RefSeq; XP_001748411.1; XM_001748359.1.
DR STRING; 81824.A9V6U2; -.
DR EnsemblProtists; EDQ86866; EDQ86866; MONBRDRAFT_10594.
DR GeneID; 5893655; -.
DR KEGG; mbr:MONBRDRAFT_10594; -.
DR InParanoid; A9V6U2; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0035255; F:ionotropic glutamate receptor binding; IBA:GO_Central.
DR GO; GO:0030160; F:synaptic receptor adaptor activity; IBA:GO_Central.
DR CDD; cd00173; SH2; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR24135:SF28; LD13733P; 1.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF55550; SH2 domain; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 32..95
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 961..1059
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1096..1143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1155..1182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..791
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..906
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1319 AA; 145910 MW; A861707F1AEF54D3 CRC64;
MFRRWRARHS SPAVIAPPRP ESPEARTGAA KWSTRDVGRW LESVHMSELK RSFKAHRIDG
NRLLALHADD LTRLGLESPS QQRLLLHNIQ QLRIVVQSSP DHGPRVSIVA AQQRVPVLHA
SQSSPLLNNA PNPLEPSQNS RDMLDFDPVY AQIHEVAPGL ESQRPGEAKV LQDNSSRGRR
PRYSSVESGD VDSYQDINRS SDSSPSPSVR DLHALYSTVS KGPRARRTTF DTADLSTYNK
NSHNFNAQQV GRHSPAPLNG ASRRRLDTDP DFVSRPRASL PTDPNNLGEH ERKHDLLIDS
LQSANRHTKT LLQAAEGAQA DESSYVPFID EEALRGNYFN DQASRHVVQD LVRQRAQRGA
FGITVPGSSG ARSSRLLLTV AVAEERIEQL PIFVAFQGLR LYADGPAFSR LAVLVEYYRH
HPLPLSDVAE DVCLSVGAFD HAALADSLTL DADASHRQTG SGDSPPAWFV GELDTESCQA
VLRYERDGCY FVRLRPPWHL EVKDPAARLH QVTSRRADDA GREPCEVVYL NGGQVGFALI
DMSPLGICLH GHENYHESLA ALLEQLRARA EELPVKLTYT PGDLTTLVDE RARRGSVDLG
FSDRGQHSLQ LSPQDMPQLL STLIPEGWRA RWWLEAPLAV QRATALLRKC PDGTFFIRHG
AQLGYFVLTY VVHGRLETES IMAFSASRSR PRPAVCVVRA SSQHYKTLSR LVQTLSQPSS
RARQLLLCPL ARNDCLMPAR LEAVQLTPPG VSNVLQQPVS RKQTQRPLLQ PPSDERLEPH
PSQERERSDS NAVLAAEPGH SAPATATSTP PHSPMARRRG ARRRSRSQSN DPADLPTRAT
NRPARLQDIK AVSAPSLFVR ADPARRSSSM HGTASAAGRS SMVGPGQPGG GRDIQRSTSL
HGTTNGAGEA PLTVREIKPI LKNTRHPFFQ KRSKTDPARI ERSVAFANSV ERVEIPAVSD
WYWYQAGKPR SAAIQELDHC PDGAFIIRRS ESNPACFALT YKALGRFWDE LVVVPSGSLY
GPGIHFDSDP RLRFRSLEEL VQYYAQPSSP LISPLIVPDS FFDSSSRSSP APFASVVLQP
RGRVPSSSTY ETLNHARQGL TSGPSSTSSS LTRLNTLNTG STHSLYESAA RVEPPREPRR
ASNFELGTQR LALKKNRPAA RVVRVPRQAA PRPARRRRSS HGTALVQPVL LAPRLQSYHR
YSAPDLKPSL ASAEAKWLDG KAKNQSWCRI HQPSHDHEAM LALSPEGSFI VRDPDLQTQP
QGMSSVHVAT LVLRTARELL YFPVLQQHKK GSPVCQTLSE LINYHSRPAN TSLPVVLRQ
//
