ID   A9V8F9_MONBE            Unreviewed;       500 AA.
AC   A9V8F9;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   RecName: Full=Argininosuccinate lyase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=MONBRDRAFT_11183 {ECO:0000313|EMBL:EDQ86075.1};
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ86075.1, ECO:0000313|Proteomes:UP000001357};
RN   [1] {ECO:0000313|EMBL:EDQ86075.1, ECO:0000313|Proteomes:UP000001357}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000256|ARBA:ARBA00010755}.
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DR   EMBL; CH991568; EDQ86075.1; -; Genomic_DNA.
DR   RefSeq; XP_001749000.1; XM_001748948.1.
DR   AlphaFoldDB; A9V8F9; -.
DR   STRING; 81824.A9V8F9; -.
DR   EnsemblProtists; EDQ86075; EDQ86075; MONBRDRAFT_11183.
DR   GeneID; 5894259; -.
DR   KEGG; mbr:MONBRDRAFT_11183; -.
DR   eggNOG; KOG1316; Eukaryota.
DR   InParanoid; A9V8F9; -.
DR   OMA; DFAIEFC; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IBA:GO_Central.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IBA:GO_Central.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR   Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 2.
DR   Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   NCBIfam; TIGR00838; argH; 1.
DR   PANTHER; PTHR43814; ARGININOSUCCINATE LYASE; 1.
DR   PANTHER; PTHR43814:SF1; ARGININOSUCCINATE LYASE; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 2.
DR   PRINTS; PR00145; ARGSUCLYASE.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; L-aspartase-like; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001357}.
FT   DOMAIN          26..178
FT                   /note="Fumarate lyase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00206"
FT   DOMAIN          201..343
FT                   /note="Fumarate lyase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00206"
FT   DOMAIN          409..476
FT                   /note="Argininosuccinate lyase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14698"
SQ   SEQUENCE   500 AA;  55154 MW;  B365B7DAAE77C3EB CRC64;
     MATTNGSAAD GPAAKKPKAE TKLWGGRFTG AVDPLMEEFN ASINVDRRMY RQDIVGSQAY
     ARAIAKVGLI TEDERDALIT GLDQVLAEWA NNQFVLQPND EDIHTANERR LKELAGPVAG
     KLHTGRSRND QVATDMRLWL RDELTELIDL LKAFVASSIE RAAADIDVLM PGYTHLQASA
     FTLLYHSTPT PCARLLPIFL RAQPIRWSHW VLSHAWAMQR DIERLTDLRK RVNVMPLGSG
     ALAGHPFGID RQALAQDLGF DAISFNSLDA TSGRDFVAEF LFAATMVNIH LSKWAEDLCN
     YSSKEFGFVQ LSDAYSTGSS LMPQKKNPDS LELIRGKAGT TFGSCAGFLM TLKGLPSTYN
     KDLQEDKSAM FQSPAVVSLT RSCVQIATGV LSTLRINPEQ MRAALSVDML ATDLAYYLVR
     RQVPFREAHG LSGQCVARAE EKKCSLNELT LEDFQAIHPK FEADVSDVWK FENSVDQYSA
     SGGTGRTAVL EQIESLKAKL
//