ID A9VAS6_MONBE Unreviewed; 1658 AA.
AC A9VAS6;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDQ85372.1};
GN ORFNames=MONBRDRAFT_29328 {ECO:0000313|EMBL:EDQ85372.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ85372.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ85372.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the SAPS family.
CC {ECO:0000256|ARBA:ARBA00006180}.
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DR EMBL; CH991574; EDQ85372.1; -; Genomic_DNA.
DR RefSeq; XP_001749783.1; XM_001749731.1.
DR STRING; 81824.A9VAS6; -.
DR EnsemblProtists; EDQ85372; EDQ85372; MONBRDRAFT_29328.
DR GeneID; 5895030; -.
DR KEGG; mbr:MONBRDRAFT_29328; -.
DR eggNOG; KOG1469; Eukaryota.
DR eggNOG; KOG2073; Eukaryota.
DR InParanoid; A9VAS6; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0003995; F:acyl-CoA dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0019903; F:protein phosphatase binding; IEA:InterPro.
DR GO; GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; IBA:GO_Central.
DR CDD; cd05154; ACAD10_11_N-like; 1.
DR Gene3D; 3.90.1200.10; -; 1.
DR Gene3D; 1.10.540.10; Acyl-CoA dehydrogenase/oxidase, N-terminal domain; 1.
DR Gene3D; 2.40.110.10; Butyryl-CoA Dehydrogenase, subunit A, domain 2; 1.
DR Gene3D; 1.20.140.10; Butyryl-CoA Dehydrogenase, subunit A, domain 3; 1.
DR InterPro; IPR041726; ACAD10_11_N.
DR InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009075; AcylCo_DH/oxidase_C.
DR InterPro; IPR037069; AcylCoA_DH/ox_N_sf.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom_sf.
DR InterPro; IPR002575; Aminoglycoside_PTrfase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR007587; SAPS.
DR PANTHER; PTHR48083:SF13; ACYL-COA DEHYDROGENASE FAMILY MEMBER 11; 1.
DR PANTHER; PTHR48083; MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR Pfam; PF01636; APH; 1.
DR Pfam; PF04499; SAPS; 2.
DR SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357}.
FT DOMAIN 959..1176
FT /note="Aminoglycoside phosphotransferase"
FT /evidence="ECO:0000259|Pfam:PF01636"
FT DOMAIN 1373..1475
FT /note="Acyl-CoA oxidase/dehydrogenase middle"
FT /evidence="ECO:0000259|Pfam:PF02770"
FT DOMAIN 1487..1636
FT /note="Acyl-CoA dehydrogenase/oxidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00441"
FT REGION 654..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..716
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..759
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1658 AA; 181695 MW; 12A67957779B4644 CRC64;
MFWEFDFNST SQIDKILDEE TCTLEQILDQ DDVLQECKAS NDKLLKYLTV EAQLDRLIRY
VVDMPDDPDE MNRFKYSSIA SEVLTCDAWS MTSAVSEAPV LNRFYAYFEQ DEVLHPLHAS
FVVRVLSGLF QKSNESMAAH LKENPQHLRS IIKHIRTPAV VELLVCISGS EMNLQDWLTS
NEHHFVEDIL SKLAPAEQQD AEELSNVHRY ISEVVINCRR EASDQWQRAG DSPPSPLLAF
LLRQDTVEQI LKDCFEGTSL SLEYSLEVLL ELVREPPIVD DDQEFSSIDR ARHKQEVQGV
LAVLAPKFSQ LHDIVVTHKR EEPLQTGSGV LEKPVGKLRL TAVHLVVALM EFRHHDMIEE
IIKAGTVGVC LAFLGDYPEN NFMHKYIFDM LSLAIPDPDN AAAGRKDEDD DSELVPTDDD
PAAAEAVNDL YRHVFVDYNL FQRLLDLWAE NNRVQSEGKG HRLGYMGYWL KIADRILALE
GSPRDPLTLF GDSDVVAGVA SSWRALVDQH IRPLLKVAKE PLGGAPPQGF ADSDDSDFYV
PRSAEDYMRV AGTGDVSDNA ADNSAAFQDF CTAELAPKFP DFRPAAHGTE ESEEDIALNY
GMDGIFSPGL VYDTDLAPFV VDGISSVQEP AYDEPAPDAL DTSMSVPIVN EAVASSTNDS
GDASAPAAAD LDSSASESES GVRTPSAVAT GGGLPLSDSS EDEDEDEEDM ADADVDEEAG
WTVKSVPMDG LARGASNEPV DEDEGDNSED KELDTDSDEE LSASYDLQTM SMTPTKPAID
IPLSPRSTNA VRHIHTRADP QASSPVAASA SDELKTFALL EQDSSTDDLS KPAAIAADDA
AGTAASPATA KSNGSNSSTP GSGVKKPERK RSLPSTPVPK NANLPSTIHT LPLSPSLSPL
SPSLSLSPSL SPLSLSLSTT KFFVKERERE REREIFMIVK HGERDRGGWL PAVKGGGVTV
RQFNNGQSNP TFWLAWPDQG PQLVVRKKPP GILLPKAHQV EREYAVLRAL YQQGFPVPEP
LLLSDDDRVI GTPFYVMRYV QGRIFRDPEL KSLPEPQRRL YYDAVVATLN LDVAQMDLPD
TMRKRGSYFG RQRHVWFKQY QLACTVVPPL PALEQLNTQL EAAAKQHTTD EQTCLTHGDF
RIDNVIFHPT EPRVIAVLDW ELCAIGHPLA DLTYFCLPFH LDSITIGDVE LPGLRASTVA
GLPTEGDVRM QYGSAAVNPQ TWAQYLGLGC LRLASIAQGV FARSRQGNAS AANASELRKV
AERLAEVGLH VMTQGQAHGD QAPKHATQLP PALRLVQLSS KAAKLRETLL RFMEEELEYA
ALAEITGRSL LAAEACNCSA PDTGNMEVLH LYGTPAQQEQ WLKPLLAGEI RSCFCMTEPD
VASSDATNMA CSISRDGDGY RINGRKWWAT GAGDPRCRLA IVMGQTPDPQ RPKHQQHSMI
LVPMDTPGVR KIRPLTHFGY DDAPHGHFEV VFDNVRVPAS NILLGEGRGF EIAQGRLGPG
RLHHCMRAIG MAERAFELML GRALTRQTFG RPLARHGMIQ EYVALSRMEI DASRLLVLQA
AHVIDQDGNK AARTHVATAK VTVARMAQAV LDRAIQVHGG AGVSADLPLA LMYAGARTLR
IADGPDEVHL VSIAAAELRR FAKAHGVTAA QLSGASKL
//
