ID A9VDM3_MONBE Unreviewed; 962 AA.
AC A9VDM3;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDQ84326.1};
GN ORFNames=MONBRDRAFT_39306 {ECO:0000313|EMBL:EDQ84326.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ84326.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ84326.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CH991589; EDQ84326.1; -; Genomic_DNA.
DR RefSeq; XP_001750822.1; XM_001750770.1.
DR AlphaFoldDB; A9VDM3; -.
DR STRING; 81824.A9VDM3; -.
DR EnsemblProtists; EDQ84326; EDQ84326; MONBRDRAFT_39306.
DR GeneID; 5896084; -.
DR KEGG; mbr:MONBRDRAFT_39306; -.
DR eggNOG; KOG0200; Eukaryota.
DR eggNOG; KOG3525; Eukaryota.
DR InParanoid; A9VDM3; -.
DR OMA; CEIACAT; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IBA:GO_Central.
DR CDD; cd00064; FU; 3.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF617; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00261; FU; 4.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..962
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002743154"
FT TRANSMEM 545..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 432..477
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 432..477
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 479..517
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 594..867
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 627
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 962 AA; 104195 MW; A7881580C10767CF CRC64;
MARWLFVLAT ILFVLGEQTS AVTSPNVLVD DVQVNAGTDL DALITALNGY TVIHGSVHIN
LTGANPGLSW ATKLEQALGA ITDIRGHLLV VNSDSILSDL SFFQNLRVIR AEDYYYFRDD
TTPDNTETAM ALVLMNYQTM TSIHLPKLHH FNNPFACYPY RIDWSRLGAL AAPGVYDSLY
PMSTLETSRW VDMTGLAATS SAYVEYCQSH TPCHEICGPI GTATCWGPGA TQCQRCTSPN
LLLAYNGSCV AACPDGYYAD DWICQPCVND CETCEGPELG ACLSCPVDFL LENGRCKSVC
TGDAVYGNVT TRTCEDCHPQ CTTCTSPLST TCTRCAEDFY LQPAPNNTVC AAECPMGYYA
SALEGSCLPC AAGCLACTGP ANCSLCDVSA DMYRLVTDVA QVCRPVSQCD SGSFASQAPT
ASSNRVCAAY TICPTGESYV TFAGNASYDR VCEPCTTCDE GMVYRLGTCE GTTPGVCVLE
NACSATPCEN GGVCSLTTSG EFQCDCSNTG FCGTICAEAL QDDGTCASEL RSRANEREAS
TATTIGASLG GVALAALLVA LIIVLLPSKR ISGAMKKRIQ ALNGGKWELE RDDVTIGQQL
GAGHFGTVSR GLLRKSDGTG NMDVAVKQLK READVDSDAA DEFFHEMKLM MDLGHHQHVV
SLVGVCTTEK PILMVIDFAN GGDLLNHLRD ARPNERREAT LREDDFRDYC AQVAAGMEFL
AFKRVIHRDL AARNVLVHDD GNGVVLKVAD FGLTVQLRND EEFRVCEDDA LPFKWLAPEC
FTDKTFSQAS DVWAFGVLMW EVYAFGQSPF PGIQNNEVYA RLGEGMRMPR PADCSKQAYD
IMMRCWKFDA AERPSFSTLL NELSAFAGKN MRDYRHSVDI TTLARAAVDL GDEAYDNTGL
VSPLEVISEE MPEGENGAPS RSSSGYVSTL TQNALAAYAA NQAREKVERS ELEAERQFVR
VK
//