ID   A9VDX4_MONBE            Unreviewed;       476 AA.
AC   A9VDX4;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   22-FEB-2023, entry version 54.
DE   RecName: Full=SH2 domain-containing protein {ECO:0000259|PROSITE:PS50001};
GN   ORFNames=MONBRDRAFT_30425 {ECO:0000313|EMBL:EDQ84294.1};
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ84294.1, ECO:0000313|Proteomes:UP000001357};
RN   [1] {ECO:0000313|EMBL:EDQ84294.1, ECO:0000313|Proteomes:UP000001357}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
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DR   EMBL; CH991591; EDQ84294.1; -; Genomic_DNA.
DR   RefSeq; XP_001750924.1; XM_001750872.1.
DR   AlphaFoldDB; A9VDX4; -.
DR   EnsemblProtists; EDQ84294; EDQ84294; MONBRDRAFT_30425.
DR   GeneID; 5896178; -.
DR   KEGG; mbr:MONBRDRAFT_30425; -.
DR   eggNOG; ENOG502QVV5; Eukaryota.
DR   InParanoid; A9VDX4; -.
DR   OMA; QSGFKHF; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR14388:SF17; SH2 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR14388; T CELL-SPECIFIC ADAPTER PROTEIN TSAD; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT   DOMAIN          370..462
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   REGION          172..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          294..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..212
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..267
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   476 AA;  54904 MW;  B340AA3A6883C89D CRC64;
     MSLLQQILET MYIDPELLEE LSKDQKEVLF HKMREEQLRR WHTRKTQDFE RLQGKKRVPR
     LKFAPSVFIY EDDDVDKKAN EAAKRLEERE KEREAAQMRA DEEQARILAE IQIQEEIERQ
     TAEQARKAEE LRIRELEEQR KLQEAALRER QAQIEREQYM SMKEARLAAE AEAKAQRARE
     EAARKLAEER AREEARLEAE RKKAEAEAQR QAEAKQQEIY MSMREMREQA RKQREMEERQ
     MDQMFQEQES RSKQHEAEQR AAAERARKAA QATENIFKQL EAHSKPAAPQ VARATNMARS
     ASLAKRPASP PPTGPGHSNT LPLPPRKGSM ADVGARPSKP SSLEDVLHWF RTSEIPRGVG
     KSATGRWENW FHGPISRPEA ERLLKGKPKG AFLLRISTRI WGYTLSFVDS DRYKHFLVDA
     SDGKYSVFGA QSNATHMSLS RLVAFHKKVA VSKTGTMLTE PVGELQGNAS LLQVVM
//