ID   A9WA68_CHLAA            Unreviewed;      1403 AA.
AC   A9WA68;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 79.
DE   SubName: Full=Adenylyl cyclase class-3/4/guanylyl cyclase {ECO:0000313|EMBL:ABY34627.1};
GN   OrderedLocusNames=Caur_1399 {ECO:0000313|EMBL:ABY34627.1};
OS   Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl).
OC   Bacteria; Chloroflexota; Chloroflexia; Chloroflexales; Chloroflexineae;
OC   Chloroflexaceae; Chloroflexus.
OX   NCBI_TaxID=324602 {ECO:0000313|EMBL:ABY34627.1, ECO:0000313|Proteomes:UP000002008};
RN   [1] {ECO:0000313|Proteomes:UP000002008}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29366 / DSM 635 / J-10-fl
RC   {ECO:0000313|Proteomes:UP000002008};
RX   PubMed=21714912; DOI=10.1186/1471-2164-12-334;
RA   Tang K.H., Barry K., Chertkov O., Dalin E., Han C.S., Hauser L.J.,
RA   Honchak B.M., Karbach L.E., Land M.L., Lapidus A., Larimer F.W.,
RA   Mikhailova N., Pitluck S., Pierson B.K., Blankenship R.E.;
RT   "Complete genome sequence of the filamentous anoxygenic phototrophic
RT   bacterium Chloroflexus aurantiacus.";
RL   BMC Genomics 12:334-334(2011).
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DR   EMBL; CP000909; ABY34627.1; -; Genomic_DNA.
DR   RefSeq; WP_012257283.1; NC_010175.1.
DR   RefSeq; YP_001635016.1; NC_010175.1.
DR   STRING; 324602.Caur_1399; -.
DR   EnsemblBacteria; ABY34627; ABY34627; Caur_1399.
DR   KEGG; cau:Caur_1399; -.
DR   PATRIC; fig|324602.8.peg.1595; -.
DR   eggNOG; COG0457; Bacteria.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG3899; Bacteria.
DR   HOGENOM; CLU_004435_4_0_0; -.
DR   InParanoid; A9WA68; -.
DR   Proteomes; UP000002008; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004016; F:adenylate cyclase activity; IBA:GO_Central.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 2.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00211; Guanylate_cyc; 2.
DR   Pfam; PF13424; TPR_12; 1.
DR   SMART; SM00044; CYCc; 2.
DR   SMART; SM00028; TPR; 6.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 3.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
DR   PROSITE; PS50005; TPR; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002008};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   DOMAIN          81..219
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   DOMAIN          316..457
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REPEAT          994..1027
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   1403 AA;  153739 MW;  6B1E8A65B21454B9 CRC64;
     MDTIMTGQLT EWRDLEGYLE PHQLADLITT GDLAAGVRAR LGSDLRARLA AHAAYIPARI
     VHQQLADPQP GRTGGSFWEG SLLFADLSGF TALSERLSEL GRQGAEEVSA IVNRLFAALL
     HEAQVRGGVL LKFGGDALTV FFDATTLNDD HALAACAAAL AMQSRMGEFA QLSTRLDNFS
     LRLRVGVHAG RVFAAEVGDQ SHIELVVTGP EVNRVALAQE IAAPGEVVVS DQILRCIAGY
     RVEPRQAGFY HLLDLQPTVI PSVPSLTWSL SGPDDLATLN RLARQLNALQ PYLVHRLPRR
     FLDPAAGELG EFRPVTVLFA NVYDFSRYLI KLDSDPELAA AIFNAYYRRV QAVVHHYEGI
     INKVDMYTHG DKLMALFGAP TAHEDDPIRA VRCALELRTV IQEANQEIGK LAGTLAPPLA
     QKIGINTGTV FAGRVGGAAR YEYTVMGPAV NLAARLMAAA PEGAIYLSPS SQMAVQDQVV
     LQAAAPLTLK GLSEPVTPAQ VVSIAPVSNR HDDEQLAVAP LIGRDAELKQ VLTTARTALR
     GRGATIALVG EAGAGKSRLA EEAIQRLVID STVHQDDYED VPPFTILFGD CQSYEQRTAY
     AAIRAPLISA LGLDARSAPD QLAANVVHRL EHLVPELSRF APLLADALAL PIADTPLTGG
     LSSQQRHDRL QELLVEIFLR LATRESLLLI LEDCHWADSP SLEVLERLSK AVSGRRLVLL
     LTYRPEMVSP APWDSHPNTI RIELGELRPE DSRALLEALL GGPPPEEMLP LLDRTQGNPF
     FIEELVRALV RDRLLIRDSA GAAWRLARPV EKIELPRSIE GLLIARLDRL DEPRQELVQV
     ASVIGRRFQR PVVEGVYSNP PVLDESLERL IDHELIQADQ QERILAYIFR HALLRDVAYE
     GILYARRRML HARVARRIEE IAAHQLEEQY AVLAWHFLQA EEWQPALHYH LLAAAQAHRR
     FANRDALALY TTALKIAPYL ATVWDPNRLI DRVAEIHEAI GDIHLTLGEY DEAERNFREA
     LQLSLPSADQ PVSERWLRLH RMLASVEERR SNYQQAFALL TEGMSRAHQG LLAETARCYL
     LGAGIAYRTG DYTHAMEWAN IGYRLAVESA SLTDQARALK IIGNIASDQG NRTQAVEALN
     QARTLYEQAN MPAGLCDVLN DLGRVYTQAG RWAETIAVFE QSMAISEAIG DVLATARTAN
     NLAVVLVGRN ELERAGKLYQ RAGELFARLG SRLGVAVTGY NRGEVLLNQG HAAAALDLFI
     TAITDLESIN ARSFLPEVLR LAALAALALE DVAGARAYAQ RSLTIAEELG QADDAAIAER
     VLGEIALAAG DLSTAAELFE RSGNTLAALG NRYELGKVRY QQARLELARK QYSTAAAARA
     EALAIFTELD AQRDLALTNA LPV
//