ID A9WED2_CHLAA Unreviewed; 732 AA.
AC A9WED2;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Proton-translocating NADH-quinone oxidoreductase, chain L {ECO:0000313|EMBL:ABY35194.1};
DE EC=1.6.99.5 {ECO:0000313|EMBL:ABY35194.1};
GN OrderedLocusNames=Caur_1979 {ECO:0000313|EMBL:ABY35194.1};
OS Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl).
OC Bacteria; Chloroflexota; Chloroflexia; Chloroflexales; Chloroflexineae;
OC Chloroflexaceae; Chloroflexus.
OX NCBI_TaxID=324602 {ECO:0000313|EMBL:ABY35194.1, ECO:0000313|Proteomes:UP000002008};
RN [1] {ECO:0000313|Proteomes:UP000002008}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29366 / DSM 635 / J-10-fl
RC {ECO:0000313|Proteomes:UP000002008};
RX PubMed=21714912; DOI=10.1186/1471-2164-12-334;
RA Tang K.H., Barry K., Chertkov O., Dalin E., Han C.S., Hauser L.J.,
RA Honchak B.M., Karbach L.E., Land M.L., Lapidus A., Larimer F.W.,
RA Mikhailova N., Pitluck S., Pierson B.K., Blankenship R.E.;
RT "Complete genome sequence of the filamentous anoxygenic phototrophic
RT bacterium Chloroflexus aurantiacus.";
RL BMC Genomics 12:334-334(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}.
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DR EMBL; CP000909; ABY35194.1; -; Genomic_DNA.
DR RefSeq; WP_012257848.1; NC_010175.1.
DR RefSeq; YP_001635583.1; NC_010175.1.
DR AlphaFoldDB; A9WED2; -.
DR SMR; A9WED2; -.
DR STRING; 324602.Caur_1979; -.
DR EnsemblBacteria; ABY35194; ABY35194; Caur_1979.
DR KEGG; cau:Caur_1979; -.
DR PATRIC; fig|324602.8.peg.2248; -.
DR eggNOG; COG1009; Bacteria.
DR HOGENOM; CLU_007100_6_1_0; -.
DR InParanoid; A9WED2; -.
DR Proteomes; UP000002008; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR Gene3D; 1.20.5.2700; -; 2.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR NCBIfam; TIGR01974; NDH_I_L; 1.
DR PANTHER; PTHR42829; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5; 1.
DR PANTHER; PTHR42829:SF2; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000313|EMBL:ABY35194.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002008};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 36..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 537..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 711..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 93..143
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 159..477
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT REGION 508..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..528
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 732 AA; 79230 MW; ABF2165C8A868FD8 CRC64;
MAFFLQYAWL IPLLPLLASA LITLTPLRRA ALASAWLATG LMMGSTVLAL GLLAAVAGGW
ALHDGQLVQL AGHHGEHGAF TFPEPNVVQR FVWAPTGDTA LQMGIYIDGA AAAMLAMVTI
ASTCIHLFSI GYMASHPRQS RFFSFIALFT AAMLLMSMAD NLLLFFMAWE IMGLCSYLLI
GFLYERPSAA RAAVKAFITT RIGDVLLLLG IVYLYAQAGG IGFGNDEGGI FFPPLLERLA
SETGALGLSH AAGIALLLFG GTVGKSAQFP LHVWLPDAME GPTPVSALIH AATMVAAGVF
LVARTFPIFT ADPTALGVVA FIGAFTALFA ATIAIAQFDI KRILAYSTLS QLGFMVAALG
VGGWVAAMFH LITHAFFKAL LFLGSGSIIH AMEQQPAIRQ IHHHDEYAAQ QTAQDIRNMG
GLRTRLPWTF WTYTAGYLAL AGIVPFAGFW SKDEILLDAF KHNLAVYLTL SAAAFLTAVY
MTRQWWLVFF GEYRGAQPVV FVNPDAPASA SDHDHHHDDH QHAHDHGEHW HEDPRMIAPL
VILASFALTA GALNLPFDLP FGHWLADVWG QEAAKLDPLV AGLSLLIAIA GIAAGWLSYR
HAFTSADDTD PLAARFPALF AVLHAKYRID ELYAATFGRL TRSLAVAWSL IDRQLIDRLI
DGMGRFTFGL GKVNFIIDDT LLNDGPDGLA SGTQGSGRQA RRLQTGKAQD YLIYVFGGLL
ALAMFWLYVV GR
//
