ID A9Y8S6_STRLN Unreviewed; 327 AA.
AC A9Y8S6;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=LmbP {ECO:0000313|EMBL:ABX00612.1};
GN ORFNames=GJU35_01465 {ECO:0000313|EMBL:QMV04461.1}, GJU35_43455
GN {ECO:0000313|EMBL:QMV11863.1}, SLCG_0241
GN {ECO:0000313|EMBL:AXG51396.1}, SLINC_0247
GN {ECO:0000313|EMBL:ANS62471.1};
OS Streptomyces lincolnensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1915 {ECO:0000313|EMBL:ABX00612.1};
RN [1] {ECO:0000313|EMBL:ABX00612.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19085073; DOI=10.1007/s12223-008-0060-8;
RA Koberska M., Kopecky J., Olsovska J., Jelinkova M., Ulanova D., Man P.,
RA Flieger M., Janata J.;
RT "Sequence analysis and heterologous expression of the lincomycin
RT biosynthetic cluster of the type strain Streptomyces lincolnensis ATCC
RT 25466.";
RL Folia Microbiol. (Praha) 53:395-401(2008).
RN [2] {ECO:0000313|EMBL:ANS62471.1, ECO:0000313|Proteomes:UP000092598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2936 {ECO:0000313|EMBL:ANS62471.1,
RC ECO:0000313|Proteomes:UP000092598};
RA Meng S.C.;
RT "Enhancement of antibiotic productionsby engineered nitrateutilization in
RT actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AXG51396.1, ECO:0000313|Proteomes:UP000253884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LC-G {ECO:0000313|EMBL:AXG51396.1,
RC ECO:0000313|Proteomes:UP000253884};
RX PubMed=29574602; DOI=10.1007/s10295-018-2029-1;
RA Xu Y., Tan G., Ke M., Li J., Tang Y., Meng S., Niu J., Wang Y., Liu R.,
RA Wu H., Bai L., Zhang L., Zhang B.;
RT "Enhanced lincomycin production by co-overexpression of metK1 and metK2 in
RT Streptomyces lincolnensis.";
RL J. Ind. Microbiol. Biotechnol. 45:345-355(2018).
RN [4] {ECO:0000313|EMBL:QMV04461.1, ECO:0000313|Proteomes:UP000515335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B48 {ECO:0000313|EMBL:QMV04461.1,
RC ECO:0000313|Proteomes:UP000515335};
RX PubMed=32322696;
RA Wang R., Kong F., Wu H., Hou B., Kang Y., Cao Y., Duan S., Ye J., Zhang H.;
RT "Complete genome sequence of high-yield strain S. lincolnensis B48 and
RT identification of crucial mutations contributing to lincomycin
RT overproduction.";
RL Synth Syst Biotechnol 5:37-48(2020).
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DR EMBL; EU124663; ABX00612.1; -; Genomic_DNA.
DR EMBL; CP016438; ANS62471.1; -; Genomic_DNA.
DR EMBL; CP022744; AXG51396.1; -; Genomic_DNA.
DR EMBL; CP046024; QMV04461.1; -; Genomic_DNA.
DR EMBL; CP046024; QMV11863.1; -; Genomic_DNA.
DR RefSeq; WP_067425661.1; NZ_CP046024.1.
DR AlphaFoldDB; A9Y8S6; -.
DR STRING; 1915.SLINC_0247; -.
DR KEGG; sls:SLINC_0247; -.
DR OrthoDB; 9812992at2; -.
DR BioCyc; MetaCyc:MONOMER-18843; -.
DR Proteomes; UP000092598; Chromosome.
DR Proteomes; UP000253884; Chromosome.
DR Proteomes; UP000515335; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR Gene3D; 3.30.230.120; -; 1.
DR InterPro; IPR001174; Galkinase.
DR InterPro; IPR013750; GHMP_kinase_C_dom.
DR InterPro; IPR036554; GHMP_kinase_C_sf.
DR InterPro; IPR006204; GHMP_kinase_N_dom.
DR InterPro; IPR014606; Heptose_7-P_kinase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR10457:SF29; LMBP PROTEIN; 1.
DR PANTHER; PTHR10457; MEVALONATE KINASE/GALACTOKINASE; 1.
DR Pfam; PF08544; GHMP_kinases_C; 1.
DR Pfam; PF00288; GHMP_kinases_N; 1.
DR PIRSF; PIRSF036406; Hept_kin; 1.
DR PRINTS; PR00960; LMBPPROTEIN.
DR SUPFAM; SSF55060; GHMP Kinase, C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000092598};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT DOMAIN 86..144
FT /note="GHMP kinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00288"
FT DOMAIN 225..304
FT /note="GHMP kinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08544"
SQ SEQUENCE 327 AA; 34254 MW; 793509AB2C3747DA CRC64;
MIDVTAPLRL SLAGGGSDLP EHYERHGCRL LAVALTAHVR LRLAEAPEGV TVRAFGTETR
AEHASSHPDP LVRAALGYFG IDRGVHLTVE SDVAPGSGLG GSGAFLVALA TALSHLTGDP
LTPAAAARAA FRIERALCGR PVGQQDHWTA ASGAAIELRI APDGTADARP DPELYEALGP
LLDHRLLLLR TPLTRSASRP LAAQARALRG KRDMTHIQSL VDDVRKALVA ADIARVGALL
HEHWTAKRAV SDAMSTPEID RWYAMVRDHG AYGAKLVGAG GGGHLLVATE AADADRLTTA
MAAEGLTRVV VGTHPLGVTA HRGEGRA
//
