ID A9YUC8_PICKU Unreviewed; 410 AA.
AC A9YUC8;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Exosome complex component RRP45 {ECO:0000313|EMBL:ONH71635.1};
DE SubName: Full=Rrp45p {ECO:0000313|EMBL:ABY26732.1};
DE EC=3.1.13.- {ECO:0000313|EMBL:ABY26732.1};
GN Name=RRP45 {ECO:0000313|EMBL:ABY26732.1};
GN ORFNames=BOH78_4372 {ECO:0000313|EMBL:ONH71635.1}, C5L36_0D02210
GN {ECO:0000313|EMBL:AWU77479.1}, CAS74_002191
GN {ECO:0000313|EMBL:OUT22456.1}, JL09_g2509
GN {ECO:0000313|EMBL:KGK38311.1};
OS Pichia kudriavzevii (Yeast) (Issatchenkia orientalis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=4909 {ECO:0000313|EMBL:ABY26732.1};
RN [1] {ECO:0000313|EMBL:ABY26732.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B2399 {ECO:0000313|EMBL:ABY26732.1};
RA Lamping E., Niimi M.D., Cannon R.D.;
RT "Innate fluconazole resistance of Candida krusei - a story about
RT aneuploidy, multi-drug efflux pumps and weak interactions of fluconazole
RT with the drug target Erg11p.";
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000029867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SD108 {ECO:0000313|Proteomes:UP000029867};
RX PubMed=25159171; DOI=10.1186/s12934-014-0121-4;
RA Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT "Exploiting Issatchenkia orientalis SD108 for succinic acid production.";
RL Microb. Cell Fact. 13:121-121(2014).
RN [3] {ECO:0000313|EMBL:KGK38311.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SD108 {ECO:0000313|EMBL:KGK38311.1};
RA Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT "Exploiting Issatchenkia orientalis SD108 for Succinic Acid Production.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Proteomes:UP000189274}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129 {ECO:0000313|Proteomes:UP000189274};
RX PubMed=28385833; DOI=10.1128/genomeA.00064-17;
RA van Rijswijck I.M.H., Derks M.F.L., Abee T., de Ridder D., Smid E.J.;
RT "Genome sequences of Cyberlindnera fabianii 65, Pichia kudriavzevii 129,
RT and Saccharomyces cerevisiae 131 isolated from fermented masau fruits in
RT Zimbabwe.";
RL Genome Announc. 5:E00064-E00064(2017).
RN [5] {ECO:0000313|EMBL:ONH71635.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129 {ECO:0000313|EMBL:ONH71635.1};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:OUT22456.1, ECO:0000313|Proteomes:UP000195871}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ckrusei653 {ECO:0000313|EMBL:OUT22456.1,
RC ECO:0000313|Proteomes:UP000195871};
RA Cuomo C., Forche A., Young S., Abouelleil A., Cao P., Chapman S.,
RA Cusick C., Shea T., Nusbaum C., Birren B.;
RT "The Genome Sequence of Candida krusei Ckrusei653.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:AWU77479.1, ECO:0000313|Proteomes:UP000249293}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS573 {ECO:0000313|EMBL:AWU77479.1,
RC ECO:0000313|Proteomes:UP000249293};
RA Douglass A.P., Offei B., Braun-Galleani S., Coughlan A.Y., Martos A.,
RA Ortiz-Merino R.A., Byrne K.P., Wolfe K.H.;
RT "Population genomics shows no distinction between pathogenic Candida krusei
RT and environmental Pichia kudriavzevii: One species, four names.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the RNase PH family.
CC {ECO:0000256|ARBA:ARBA00006678}.
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DR EMBL; EU296425; ABY26732.1; -; Genomic_DNA.
DR EMBL; EU296426; ABY26736.1; -; Genomic_DNA.
DR EMBL; EU296427; ABY26740.1; -; Genomic_DNA.
DR EMBL; CP028776; AWU77479.1; -; Genomic_DNA.
DR EMBL; JQFK01000021; KGK38311.1; -; Genomic_DNA.
DR EMBL; MQVM01000031; ONH71635.1; -; Genomic_DNA.
DR EMBL; NHMM01000003; OUT22456.1; -; Genomic_DNA.
DR AlphaFoldDB; A9YUC8; -.
DR STRING; 4909.A9YUC8; -.
DR VEuPathDB; FungiDB:C5L36_0D02210; -.
DR eggNOG; KOG1614; Eukaryota.
DR HOGENOM; CLU_038194_0_0_1; -.
DR OrthoDB; 128403at2759; -.
DR Proteomes; UP000029867; Unassembled WGS sequence.
DR Proteomes; UP000189274; Unassembled WGS sequence.
DR Proteomes; UP000195871; Unassembled WGS sequence.
DR Proteomes; UP000249293; Chromosome 4.
DR GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IEA:UniProt.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:UniProt.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProt.
DR GO; GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IEA:UniProt.
DR GO; GO:0016075; P:rRNA catabolic process; IEA:UniProt.
DR CDD; cd11368; RNase_PH_RRP45; 1.
DR Gene3D; 3.30.230.70; GHMP Kinase, N-terminal domain; 1.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR015847; ExoRNase_PH_dom2.
DR InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR033100; Rrp45.
DR PANTHER; PTHR11097:SF14; EXOSOME COMPLEX COMPONENT RRP45; 1.
DR PANTHER; PTHR11097; EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN; 1.
DR Pfam; PF01138; RNase_PH; 2.
DR Pfam; PF03725; RNase_PH_C; 1.
DR SUPFAM; SSF55666; Ribonuclease PH domain 2-like; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000313|EMBL:ABY26732.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000249293};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 39..105
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF01138"
FT DOMAIN 160..229
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF01138"
FT DOMAIN 320..373
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF03725"
FT REGION 118..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 44433 MW; 42F59F1CA5FE3061 CRC64;
MTHTDNTLPI PNILTLHSLL SGHPPLRPSL RALDEPRNLE INIVSSSESA SQRSVEVKLG
ETYVSCKVSA QITQPYEDRP FEGTFAISTE ITAMCSPAFS NSNNTDFSTA APAIVPATSV
NVPSNGESNN NNNSNNGSGS GNQENQLSMG GGAVMGLAAD QGATEILLGR LIEKGVRRSN
ALDLESLCII AGQKCWAVRA DVRFLNYDGN LVDAASIAVI TALLHFRKPD VELVGSGEGT
ELIIYDEKQR EMVPLSILHI PICVTFQFFS TESVERNIKG ESLDSRSRSR QVKSNNGDEG
DDDLMDVDYE ANDGPRASNE VVIVDATSEE ELLSQGSMTV TLNSNKELCQ ISKSGGLNVD
SKKVLECCQI ASKIVDKWTK QIKQVLADDE KKRRNPLIEK TLSTVNDRSS
//
