ID AARE1_ORYSJ Reviewed; 775 AA.
AC Q0IXP9; A0A0P0XU57; Q338C1;
DT 16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=Acylamino-acid-releasing enzyme 1 {ECO:0000305};
DE Short=AARE1 {ECO:0000305};
DE EC=3.4.19.1 {ECO:0000305};
GN OrderedLocusNames=Os10g0415600 {ECO:0000312|EMBL:BAF26516.1},
GN LOC_Os10g28020 {ECO:0000312|EMBL:ABB47613.1};
GN ORFNames=OsJ_31520 {ECO:0000312|EMBL:EEE50961.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12791992; DOI=10.1126/science.1083523;
RA Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S.,
RA Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D.,
RA Oates R., Palmer M., Pries G., Gibson J., Anderson H., Paradkar M.,
RA Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F.,
RA Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M.,
RA Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R.,
RA Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F.,
RA Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D.,
RA Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R.,
RA Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K.,
RA Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S.,
RA Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S.,
RA Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R.,
RA Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M.,
RA Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R.,
RA Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E.,
RA Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.;
RT "In-depth view of structure, activity, and evolution of rice chromosome
RT 10.";
RL Science 300:1566-1569(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: Catalyzes the hydrolysis of the N-terminal peptide bond of an
CC N-acetylated peptide to generate an N-acetylated amino acid and a
CC peptide with a free N-terminus. {ECO:0000250|UniProtKB:Q84LM4}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of an N-acetyl or N-formyl amino acid from the N-
CC terminus of a polypeptide.; EC=3.4.19.1; Evidence={ECO:0000305};
CC -!- SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:Q84LM4}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q84LM4}.
CC -!- SIMILARITY: Belongs to the peptidase S9C family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABB47613.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAT10848.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EEE50961.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DP000086; ABB47613.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008216; BAF26516.1; -; Genomic_DNA.
DR EMBL; AP014966; BAT10848.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CM000147; EEE50961.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_015614198.1; XM_015758712.1.
DR RefSeq; XP_015614199.1; XM_015758713.1.
DR AlphaFoldDB; Q0IXP9; -.
DR SMR; Q0IXP9; -.
DR STRING; 39947.Q0IXP9; -.
DR ESTHER; orysa-q7xem8; ACPH_Peptidase_S9.
DR PaxDb; 39947-Q0IXP9; -.
DR GeneID; 4348626; -.
DR KEGG; osa:4348626; -.
DR eggNOG; KOG2100; Eukaryota.
DR HOGENOM; CLU_014230_1_1_1; -.
DR InParanoid; Q0IXP9; -.
DR OrthoDB; 2877590at2759; -.
DR Proteomes; UP000000763; Chromosome 10.
DR Proteomes; UP000007752; Chromosome 10.
DR Proteomes; UP000059680; Chromosome 10.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008242; F:omega peptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR045550; AARE_N.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR001375; Peptidase_S9.
DR PANTHER; PTHR42776:SF30; ACYLAMINO-ACID-RELEASING ENZYME 1; 1.
DR PANTHER; PTHR42776; SERINE PEPTIDASE S9 FAMILY MEMBER; 1.
DR Pfam; PF19283; APEH_N; 1.
DR Pfam; PF07676; PD40; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase; Reference proteome.
FT CHAIN 1..775
FT /note="Acylamino-acid-releasing enzyme 1"
FT /id="PRO_0000435686"
FT ACT_SITE 627
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10084"
FT ACT_SITE 718
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10084"
FT ACT_SITE 750
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10084"
SQ SEQUENCE 775 AA; 84940 MW; 9224147E7DCB0086 CRC64;
MATTQASEAA TEKGLPLGMD VSMVDEYASQ SKLLQEFVKI PTIGNAWIFN SKTENTSRAI
VSVGQTDLLA NKKRSFLLNS HISKNSSNSV DFQWSPFPIE MSGVSAVIPS PSGRKLLLIR
NSEDDSPTKL EVWGPCQLEN EIHIAQSVHG SLYVDEWFEG ISWNQEETLV AYVAEEPPQP
KPEFNDSGYK KAGSSEKDCK SWKGKGDWEE TWGETYSKKR IPALFVVNIS SGEVRAVKGI
PRTLSVGQVI WAPSSSHSLV FVAWSSDNGY QKTPRKLGIK YCFNRPCALY AVPDPFMEEA
DKPSLNVSKG ETAPTTKLTS ELSSAFFPRF SPDGKYLVFI SAKSAIDSGT HNATNSMHKI
DWPADGKLEG LSVADVVPIV MCPQDGCFPG LYCSGILRNP WLTDGQTMIL SSIWGSKEVI
LSVNVVSREV SRVSPQDSDY SWNVLALDKD NILAVSSSLI TVPQIYYGSE VCQTGKPNQW
EWQEIATPFP SPSDKISAIL ADHKFSILKI PISNSSNKLA DGAKLPFEAI FVSWKDSATR
PTIVVLHGGP HTVYPSSYSK SLAFLYSQGY NLLVVNYRGS LGFGEEALQS LPGNIGSQDV
NDVLTALDFV IKKGLIDASK VAVVGGSHGG FLTTHLIGQA PGTFVAAAAR NPVCNLSLMV
GTTDIPEWCF VEIYGKEGKN CFSEYPSFDD LCQFHQKSPI SHISKVSTPT LFLLGAQDLR
VPVSNGLQYA RTLKEMGVET KIIVFPEDMH GLDKPQSDFE SFLNIGVWFK KHMSK
//
