ID AATPI_ARATH Reviewed; 505 AA.
AC Q9FN75; Q3E9G3;
DT 11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 151.
DE RecName: Full=AAA-ATPase At5g17760;
DE EC=3.6.1.- {ECO:0000250|UniProtKB:Q9FLD5};
GN OrderedLocusNames=At5g17760 {ECO:0000312|EMBL:AED92464.1};
GN ORFNames=MVA3.12 {ECO:0000312|EMBL:BAB09575.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence
RT features of the regions of 1,044,062 bp covered by thirteen physically
RT assigned P1 clones.";
RL DNA Res. 4:291-300(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000250|UniProtKB:Q9FLD5};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000250|UniProtKB:Q9FLD5};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9FN75-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9FN75-2; Sequence=VSP_057975, VSP_057976;
CC -!- SIMILARITY: Belongs to the AAA ATPase family. BCS1 subfamily.
CC {ECO:0000305}.
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DR EMBL; AB006706; BAB09575.1; -; Genomic_DNA.
DR EMBL; CP002688; AED92464.1; -; Genomic_DNA.
DR EMBL; CP002688; AED92465.1; -; Genomic_DNA.
DR RefSeq; NP_568357.1; NM_121782.3. [Q9FN75-2]
DR RefSeq; NP_850841.1; NM_180510.2. [Q9FN75-1]
DR AlphaFoldDB; Q9FN75; -.
DR SMR; Q9FN75; -.
DR STRING; 3702.Q9FN75; -.
DR iPTMnet; Q9FN75; -.
DR PaxDb; 3702-AT5G17760-1; -.
DR ProteomicsDB; 244612; -. [Q9FN75-1]
DR EnsemblPlants; AT5G17760.1; AT5G17760.1; AT5G17760. [Q9FN75-1]
DR EnsemblPlants; AT5G17760.2; AT5G17760.2; AT5G17760. [Q9FN75-2]
DR GeneID; 831644; -.
DR Gramene; AT5G17760.1; AT5G17760.1; AT5G17760. [Q9FN75-1]
DR Gramene; AT5G17760.2; AT5G17760.2; AT5G17760. [Q9FN75-2]
DR KEGG; ath:AT5G17760; -.
DR Araport; AT5G17760; -.
DR TAIR; AT5G17760; -.
DR eggNOG; KOG0743; Eukaryota.
DR HOGENOM; CLU_010189_0_1_1; -.
DR InParanoid; Q9FN75; -.
DR OMA; MGMDNEI; -.
DR OrthoDB; 819832at2759; -.
DR PhylomeDB; Q9FN75; -.
DR PRO; PR:Q9FN75; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FN75; baseline and differential.
DR Genevisible; Q9FN75; AT.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006950; P:response to stress; IEA:UniProt.
DR CDD; cd19510; RecA-like_BCS1; 1.
DR Gene3D; 6.10.280.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR025753; AAA_N_dom.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23070:SF168; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23070; BCS1 AAA-TYPE ATPASE; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF14363; AAA_assoc; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW Alternative splicing; ATP-binding; Hydrolase; Magnesium; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..505
FT /note="AAA-ATPase At5g17760"
FT /id="PRO_0000434720"
FT TRANSMEM 11..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 136..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 260..267
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 337..341
FT /note="GPLTL -> VRFLL (in isoform 2)"
FT /id="VSP_057975"
FT VAR_SEQ 342..505
FT /note="Missing (in isoform 2)"
FT /id="VSP_057976"
SQ SEQUENCE 505 AA; 57459 MW; 3EE3DB5924E089FD CRC64;
MFFSKDLPSP TSVFTAYASM AGYMMMIRSM AHELIPAPLQ DFIYRTLRSL FFRSSSSTLT
LTIDDDNMGM NNEIYRAAQT YLSTKISPDA VRLRISKGHK DKHVNLYLSD GEIVNDVYED
VQLVWRFVTD GGDKKGGGGG VGGRGGGGGR RGGMDDDGKS EYFELSFDKK HKDLILNSYV
PYIESKAKEI RDERRILMLH SLNSLRWESV ILEHPSTFET MAMEDDLKRD VIEDLDRFIR
RKEFYKRVGK AWKRGYLLYG PPGTGKSSLV AAMANYLKFD VYDLQLASVM RDSDLRRLLL
ATRNRSILVI EDIDCAVDLP NRIEQPVEGK NRGESQGPLT LSGLLNFIDG LWSSCGDERI
IIFTTNHKDR LDPALLRPGR MDMHIYMGHC SFQGFKTLAS NYLGLSDAAM PHRLFPEIER
LIDGEVMTPA QVAEELMKSE DADVALEGLV NVLEKMRLKS KESNPVMMKQ KESRLEMEEM
RLKSDTEGSP RKNSKRFKKL VLFWT
//
