ID ABITM_CHICK Reviewed; 173 AA.
AC Q5ZHW7;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 24-JAN-2024, entry version 77.
DE RecName: Full=Protein Abitram {ECO:0000305};
DE AltName: Full=Actin-binding transcription modulator;
DE AltName: Full=Protein Simiate;
GN Name=ABITRAM; Synonyms=FAM206A; ORFNames=RCJMB04_32i4;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Actin-binding protein that regulates actin polymerization,
CC filopodia dynamics and increases the branching of proximal dendrites of
CC developing neurons. {ECO:0000250|UniProtKB:Q80ZQ9}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q80ZQ9}.
CC Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q80ZQ9}. Nucleus
CC {ECO:0000250|UniProtKB:Q80ZQ9}. Cell projection, growth cone
CC {ECO:0000250|UniProtKB:Q80ZQ9}. Cell projection, dendrite
CC {ECO:0000250|UniProtKB:Q80ZQ9}. Note=Localizes to somata and dendrites
CC in cortical neurons. Colocalizes with actin in lamellipodia.
CC {ECO:0000250|UniProtKB:Q80ZQ9}.
CC -!- SIMILARITY: Belongs to the ABITRAM family. {ECO:0000305}.
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DR EMBL; AJ721017; CAG32676.1; -; mRNA.
DR RefSeq; NP_001006383.1; NM_001006383.1.
DR AlphaFoldDB; Q5ZHW7; -.
DR SMR; Q5ZHW7; -.
DR STRING; 9031.ENSGALP00000072766; -.
DR PaxDb; 9031-ENSGALP00000030345; -.
DR GeneID; 420983; -.
DR KEGG; gga:420983; -.
DR CTD; 420983; -.
DR VEuPathDB; HostDB:geneid_420983; -.
DR eggNOG; KOG3266; Eukaryota.
DR InParanoid; Q5ZHW7; -.
DR PhylomeDB; Q5ZHW7; -.
DR PRO; PR:Q5ZHW7; -.
DR Proteomes; UP000000539; Unassembled WGS sequence.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0032433; C:filopodium tip; ISS:UniProtKB.
DR GO; GO:0030426; C:growth cone; ISS:UniProtKB.
DR GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0003785; F:actin monomer binding; IBA:GO_Central.
DR GO; GO:0048813; P:dendrite morphogenesis; ISS:UniProtKB.
DR GO; GO:0030833; P:regulation of actin filament polymerization; ISS:UniProtKB.
DR GO; GO:0051489; P:regulation of filopodium assembly; ISS:UniProtKB.
DR Gene3D; 2.40.50.100; -; 1.
DR InterPro; IPR039169; Abitram.
DR InterPro; IPR033753; GCV_H/Fam206.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR13651:SF0; PROTEIN ABITRAM; 1.
DR PANTHER; PTHR13651; UNCHARACTERIZED; 1.
DR Pfam; PF01597; GCV_H; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; Cell projection; Nucleus; Reference proteome.
FT CHAIN 1..173
FT /note="Protein Abitram"
FT /id="PRO_0000291931"
SQ SEQUENCE 173 AA; 19199 MW; B6E8F63F19DCEF73 CRC64;
MAAAEALGAA RYFTRWYKAD VKGRPCEDFC VLQHSNRICV ITLAEAHPLL QPGKTITSIN
YQISPNCSRL QNKVSGKSKR GAQFLTELAP LCRIASSDGE EYTIYSFIRG RLIEVNENIL
SNPALLQEKP STEGYIAVVL PKFEESKSVT QGLLTPEEYK EVLLKRQNSS SGS
//
