ID ACTY_BOVIN Reviewed; 376 AA.
AC A4IFE3;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 82.
DE RecName: Full=Beta-centractin;
DE AltName: Full=Actin-related protein 1B;
DE Short=ARP1B;
GN Name=ACTR1B;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of a multi-subunit complex involved in microtubule
CC based vesicle motility. It is associated with the centrosome (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the actin family. ARP1 subfamily. {ECO:0000305}.
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DR EMBL; BC134541; AAI34542.1; -; mRNA.
DR RefSeq; NP_001096808.1; NM_001103338.1.
DR AlphaFoldDB; A4IFE3; -.
DR SMR; A4IFE3; -.
DR CORUM; A4IFE3; -.
DR STRING; 9913.ENSBTAP00000059768; -.
DR PaxDb; 9913-ENSBTAP00000028053; -.
DR PeptideAtlas; A4IFE3; -.
DR Ensembl; ENSBTAT00000081801.1; ENSBTAP00000059768.1; ENSBTAG00000048041.2.
DR GeneID; 100125305; -.
DR KEGG; bta:100125305; -.
DR CTD; 10120; -.
DR VEuPathDB; HostDB:ENSBTAG00000048041; -.
DR VGNC; VGNC:54395; ACTR1B.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000161587; -.
DR InParanoid; A4IFE3; -.
DR OMA; YTTWTGG; -.
DR OrthoDB; 10at2759; -.
DR Reactome; R-BTA-2132295; MHC class II antigen presentation.
DR Reactome; R-BTA-6798695; Neutrophil degranulation.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000048041; Expressed in cardiac atrium and 106 other cell types or tissues.
DR ExpressionAtlas; A4IFE3; baseline.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; ISS:AgBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR InterPro; IPR004001; Actin_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; ACTIN; 1.
DR PANTHER; PTHR11937:SF195; BETA-CENTRACTIN; 1.
DR Pfam; PF00022; Actin; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00432; ACTINS_2; 1.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE 2: Evidence at transcript level;
KW Acetylation; ATP-binding; Cytoplasm; Cytoskeleton; Nitration;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..376
FT /note="Beta-centractin"
FT /id="PRO_0000328040"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P42025"
FT MOD_RES 4
FT /note="3'-nitrotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q8R5C5"
SQ SEQUENCE 376 AA; 42294 MW; 79C55A3104DF91D4 CRC64;
MESYDIIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHMRVMAG ALEGDLFIGP
KAEEHRGLLA IRYPMEHGVV RDWNDMERIW QYVYSKDQLQ TFSEEHPVLL TEAPLNPSKN
REKAAEVFFE TFNVPALFIS MQAVLSLYAT GRTTGVVLDS GDGVTHAVPV YEGFAMPHSI
MRVDIAGRDV SRYLRLLLRK EGADFHTSAE FEVVRTIKER ACYLSINPQK DEALETEKVQ
YTLPDGSTLN VGPARFRAPE LLFQPDLIGD ESEGLHEVLV FAIHKSDMDL RRTLFANIML
SGGSTLFKGF GDRLLSEVKK LAPKDVKIKI SAPQERLYST WIGGSILASL DTFKKMWVSK
KEYEEDGSRA IHRKTF
//
