ID ADEC2_CARHZ Reviewed; 570 AA.
AC Q3AE81;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Adenine deaminase 2 {ECO:0000255|HAMAP-Rule:MF_01518};
DE Short=Adenase 2 {ECO:0000255|HAMAP-Rule:MF_01518};
DE Short=Adenine aminase 2 {ECO:0000255|HAMAP-Rule:MF_01518};
DE EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN Name=ade2 {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=CHY_0699;
OS Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 /
OS Z-2901).
OC Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Carboxydothermus.
OX NCBI_TaxID=246194;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-161 / DSM 6008 / Z-2901;
RX PubMed=16311624; DOI=10.1371/journal.pgen.0010065;
RA Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J.,
RA Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J.,
RA Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A.;
RT "Life in hot carbon monoxide: the complete genome sequence of
RT Carboxydothermus hydrogenoformans Z-2901.";
RL PLoS Genet. 1:563-574(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR EMBL; CP000141; ABB15047.1; -; Genomic_DNA.
DR RefSeq; WP_011343629.1; NC_007503.1.
DR AlphaFoldDB; Q3AE81; -.
DR SMR; Q3AE81; -.
DR STRING; 246194.CHY_0699; -.
DR KEGG; chy:CHY_0699; -.
DR eggNOG; COG1001; Bacteria.
DR HOGENOM; CLU_027935_0_0_9; -.
DR InParanoid; Q3AE81; -.
DR OrthoDB; 9775607at2; -.
DR Proteomes; UP000002706; Chromosome.
DR GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR CDD; cd01295; AdeC; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.30.40.10; Urease, subunit C, domain 1; 1.
DR HAMAP; MF_01518; Adenine_deamin; 1.
DR InterPro; IPR006679; Adenine_deam.
DR InterPro; IPR026912; Adenine_deam_C.
DR InterPro; IPR006680; Amidohydro-rel.
DR InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01178; ade; 1.
DR PANTHER; PTHR11113:SF2; ADENINE DEAMINASE; 1.
DR PANTHER; PTHR11113; N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE; 1.
DR Pfam; PF13382; Adenine_deam_C; 1.
DR Pfam; PF01979; Amidohydro_1; 1.
DR SUPFAM; SSF51338; Composite domain of metallo-dependent hydrolases; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase; Manganese; Reference proteome.
FT CHAIN 1..570
FT /note="Adenine deaminase 2"
FT /id="PRO_0000292378"
SQ SEQUENCE 570 AA; 61600 MW; 47EFFF8C00F1B291 CRC64;
MKPIKDLVEV ALGKKPADLV LKNAQVFNSF TGEFVTGDVA VVAGYIAGTG EYEGKTTYDL
QGAYVTPGFI DGHVHIESSM VAPAEFARAL VPAGTLTAVV DPHEIANVSG TAGIRYMLEA
SSNLPINIYL MLPSCVPATS LETAGAVLTA RELSEFINHP RVLGLGELMD YPGVLNTHEE
MLKKLAVTEG KLIDGHAPGI SGKELTAYIA AGVNSEHECT TAEEARERLS RGMYLMLREG
SATKNLLDLL PAVDRYTASR CFFVTDDRHP EDLIKLGSIN HMVKLAVSAG ADLPTVLQMA
TINAANYFRL YDLGAIAPGY RADILVFEDL QEFKPKYVFK DGKLVAENGK PLFTGYPVDD
RAVRNTMRLK EINPEKLKIP AKSNRARVIG LIPHQIVTKK LELEVPVEGG YFKTSTEKDI
AKLAVFERHN YTGNVGVGLI HGLGLKKGAI ASTVAHDSHN LVVAGMSDED IIAAVEELKR
IGGGLTVVAD GQVLGSLPLP IAGLMSDRTL YEVQEELEKL HRIVRNLGVS ENYDPFMTLA
FLSLPVIPEL KLTDLGLVDV STFSVVPVSL
//
